Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space
Abstract
:1. Introduction
2. The CoV Budding Compartment
3. The Assembly and Exit Strategies of CoVs Are Not Unique
4. CoV Assembly at the IC Membranes
5. A Viral Perspective on IC Organization
6. Golgi Stack-Independent Secretion of CoVs
7. Mechanisms and Consequences of CoV-Induced Golgi Disassembly
8. Passage of Large Cargo across the Golgi Ribbon
9. Summary and Perspectives
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Abbreviations
BFA | Brefeldin A |
COPI | coatomer protein I |
CoV | coronavirus |
EM | electron microscopy |
ER | endoplasmic reticulum |
ERES | ER exit site |
ERGIC | ER-Golgi intermediate compartment |
GalNAc | N-acetyl-galactosamine |
GM130 | Golgi matrix protein of 130 kD |
GRASP65 | Golgi reassembly and stacking protein of 65 kD |
HCV | hepatitis C virus |
IBV | avian infectious bronchitis virus |
IC | pre-Golgi intermediate compartment |
KDEL-receptor | Lys-Asp-Glu-Leu tetrapeptide receptor |
LAMP-1 | lysosome-associated membrane protein-1 |
MHV | mouse hepatitis virus |
MT | microtubule |
PM | plasma membrane |
Rab | rat brain |
RE | recycling endosome |
TANGO-1 | transport and Golgi organization protein-1 |
TGN | trans-Golgi network |
VLDL | very low density lipoprotein |
VLP | virus-like particle |
VTC | vesicular tubular cluster |
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Saraste, J.; Prydz, K. Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space. Cells 2021, 10, 503. https://doi.org/10.3390/cells10030503
Saraste J, Prydz K. Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space. Cells. 2021; 10(3):503. https://doi.org/10.3390/cells10030503
Chicago/Turabian StyleSaraste, Jaakko, and Kristian Prydz. 2021. "Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space" Cells 10, no. 3: 503. https://doi.org/10.3390/cells10030503