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Cells
Volume 10
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10.3390/cells10040955
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Review

MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives

by
Francesca Galuppini
1,
Simona Censi
2,
Margherita Moro
1,
Stefano Carraro
1,
Marta Sbaraglia
1,
Maurizio Iacobone
3,
Matteo Fassan
1,4,
Caterina Mian
2 and
Gianmaria Pennelli
1,*
1
Pathology Unit, Department of Medicine, University of Padua, Via Gabelli 61, 35121 Padua, Italy
2
Endocrinology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35121 Padua, Italy
3
Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
4
Istituto Oncologico del Veneto, IOV-IRCCS, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Cells 2021, 10(4), 955; https://doi.org/10.3390/cells10040955
Submission received: 31 March 2021 / Revised: 15 April 2021 / Accepted: 16 April 2021 / Published: 20 April 2021
(This article belongs to the Collection Regulatory Functions of microRNAs)
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Abstract

Medullary thyroid carcinoma (MTC) is a rare malignant neoplasia with a variable clinical course, with complete remission often difficult to achieve. Genetic alterations lead to fundamental changes not only in hereditary MTC but also in the sporadic form, with close correlations between mutational status and prognosis. In recent years, microRNAs (miRNAs) have become highly relevant as crucial players in MTC etiology. Current research has focused on their roles in disease carcinogenesis and development, but recent studies have expounded their potential as biomarkers and response predictors to novel biological drugs for advanced MTC. One such element which requires greater investigation is their mechanism of action and the molecular pathways involved in the regulation of gene expression. A more thorough understanding of these mechanisms will help realize the promising potential of miRNAs for MTC therapy and management.
Keywords: microRNA; medullary thyroid carcinoma; miR-21; miR-375; biomarkers; circulating microRNA microRNA; medullary thyroid carcinoma; miR-21; miR-375; biomarkers; circulating microRNA

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MDPI and ACS Style

Galuppini, F.; Censi, S.; Moro, M.; Carraro, S.; Sbaraglia, M.; Iacobone, M.; Fassan, M.; Mian, C.; Pennelli, G. MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives. Cells 2021, 10, 955. https://doi.org/10.3390/cells10040955

AMA Style

Galuppini F, Censi S, Moro M, Carraro S, Sbaraglia M, Iacobone M, Fassan M, Mian C, Pennelli G. MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives. Cells. 2021; 10(4):955. https://doi.org/10.3390/cells10040955

Chicago/Turabian Style

Galuppini, Francesca, Simona Censi, Margherita Moro, Stefano Carraro, Marta Sbaraglia, Maurizio Iacobone, Matteo Fassan, Caterina Mian, and Gianmaria Pennelli. 2021. "MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives" Cells 10, no. 4: 955. https://doi.org/10.3390/cells10040955

APA Style

Galuppini, F., Censi, S., Moro, M., Carraro, S., Sbaraglia, M., Iacobone, M., Fassan, M., Mian, C., & Pennelli, G. (2021). MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives. Cells, 10(4), 955. https://doi.org/10.3390/cells10040955

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