Next Article in Journal
The Ultimate (Mis)match: When DNA Meets RNA
Next Article in Special Issue
The Roadmap of RANKL/RANK Pathway in Cancer
Previous Article in Journal
The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells
Previous Article in Special Issue
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 10
Issue 6
10.3390/cells10061432
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Sarcoma Metabolomics: Current Horizons and Future Perspectives

by
Miguel Esperança-Martins
1,2,3,*,
Isabel Fernandes
1,3,4,
Joaquim Soares do Brito
4,5,
Daniela Macedo
6,
Hugo Vasques
4,7,
Teresa Serafim
2,
Luís Costa
1,3,4 and
Sérgio Dias
2,4
1
Centro Hospitalar Universitário Lisboa Norte, Medical Oncology Department, Hospital Santa Maria, 1649-028 Lisboa, Portugal
2
Vascular Biology & Cancer Microenvironment Lab, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
3
Translational Oncobiology Lab, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
4
Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
5
Centro Hospitalar Universitário Lisboa Norte, Orthopedics and Traumatology Department, Hospital Santa Maria, 1649-028 Lisboa, Portugal
6
Medical Oncology Department, Hospital Lusíadas Lisboa, 1500-458 Lisboa, Portugal
7
General Surgery Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Cells 2021, 10(6), 1432; https://doi.org/10.3390/cells10061432
Submission received: 31 March 2021 / Revised: 29 May 2021 / Accepted: 4 June 2021 / Published: 8 June 2021
(This article belongs to the Special Issue Translational Oncobiology: From Molecular Mechanisms to Targeted Therapies)
Browse Figures
Versions Notes

Abstract

The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.
Keywords: sarcoma; soft tissue sarcoma; bone sarcoma; gastrointestinal stromal tumor; metabolomics; metabolism sarcoma; soft tissue sarcoma; bone sarcoma; gastrointestinal stromal tumor; metabolomics; metabolism

Share and Cite

MDPI and ACS Style

Esperança-Martins, M.; Fernandes, I.; Soares do Brito, J.; Macedo, D.; Vasques, H.; Serafim, T.; Costa, L.; Dias, S. Sarcoma Metabolomics: Current Horizons and Future Perspectives. Cells 2021, 10, 1432. https://doi.org/10.3390/cells10061432

AMA Style

Esperança-Martins M, Fernandes I, Soares do Brito J, Macedo D, Vasques H, Serafim T, Costa L, Dias S. Sarcoma Metabolomics: Current Horizons and Future Perspectives. Cells. 2021; 10(6):1432. https://doi.org/10.3390/cells10061432

Chicago/Turabian Style

Esperança-Martins, Miguel, Isabel Fernandes, Joaquim Soares do Brito, Daniela Macedo, Hugo Vasques, Teresa Serafim, Luís Costa, and Sérgio Dias. 2021. "Sarcoma Metabolomics: Current Horizons and Future Perspectives" Cells 10, no. 6: 1432. https://doi.org/10.3390/cells10061432

APA Style

Esperança-Martins, M., Fernandes, I., Soares do Brito, J., Macedo, D., Vasques, H., Serafim, T., Costa, L., & Dias, S. (2021). Sarcoma Metabolomics: Current Horizons and Future Perspectives. Cells, 10(6), 1432. https://doi.org/10.3390/cells10061432

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop