Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction
Abstract
:1. Introduction
2. Neutrophil-Mediated Cardiac Injury
2.1. Neutrophil Respiratory Burst, Degranulation, Secretion of Inflammatory Mediators, and No-Reflow Induced by Neutrophils
2.2. Neutrophil Extracellular Traps (NETs)
2.3. Extracellular Vesicles (EVs)
2.4. Aggravating Granulopoiesis by Neutrophils
3. Neutrophil-Dependent Myocardial Repair
3.1. Phagocytosis of Tissue and Cellular Debris by Neutrophils
3.2. Inflammation Resolution Promoted by Apoptotic Neutrophils
3.3. Inducing a Pro-Reparative Macrophage Phenotype by Neutrophils
3.4. Pro-Angiogenic Neutrophils
3.5. Neutrophil Generation of Specialized Pro-Resolving Mediators (SPMs)
3.6. Regulation of Fibroblast Functions by Neutrophils
4. Neutrophil Heterogeneity and Plasticity
5. Neutrophils and Adaptive Immunity
6. Anti-Neutrophil Strategies and Future Perspectives
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ma, Y. Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction. Cells 2021, 10, 1676. https://doi.org/10.3390/cells10071676
Ma Y. Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction. Cells. 2021; 10(7):1676. https://doi.org/10.3390/cells10071676
Chicago/Turabian StyleMa, Yonggang. 2021. "Role of Neutrophils in Cardiac Injury and Repair Following Myocardial Infarction" Cells 10, no. 7: 1676. https://doi.org/10.3390/cells10071676