Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa

Sánchez-Cruz, Alonso; Hernández-Fuentes, María D.; Murillo-Gómez, Cayetana; de la Rosa, Enrique J.; Hernández-Sánchez, Catalina

doi:10.3390/cells11101621

Open AccessArticle

Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa

by

Alonso Sánchez-Cruz

^1,†,

María D. Hernández-Fuentes

^1,†

,

Cayetana Murillo-Gómez

¹,

Enrique J. de la Rosa

¹ and

Catalina Hernández-Sánchez

^1,2,*

¹

Department of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CSIC), 28040 Madrid, Spain

²

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM-ISCIII), 28034 Madrid, Spain

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Cells 2022, 11(10), 1621; https://doi.org/10.3390/cells11101621

Submission received: 7 March 2022 / Revised: 3 May 2022 / Accepted: 10 May 2022 / Published: 12 May 2022

(This article belongs to the Special Issue Insulin-Degrading Enzyme in Health and Disease)

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Abstract

Insulin-degrading enzyme (IDE) was named after its role as a proteolytic enzyme of insulin. However, recent findings suggest that IDE is a widely expressed, multitask protein, with both proteolytic and non-proteolytic functions. Here, we characterize the expression of IDE in the mammalian retina in both physiological and pathological conditions. We found that IDE was enriched in cone inner segments. IDE levels were downregulated in the dystrophic retina of several mouse models of retinitis pigmentosa carrying distinct mutations. In rd10 mice, a commonly studied mouse model of retinitis pigmentosa, treatment with an IDE activator (a synthetic peptide analog of preimplantation factor) delayed loss of visual function and preserved photoreceptor cells. Together, these results point to potential novel roles for IDE in retinal physiology and disease, further extending the list of diverse functions attributed to this enzyme.

Keywords: insulin-degrading enzyme; retinitis pigmentosa; retina; neurodegeneration; rd1; rd10; P23H; preimplantation factor

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MDPI and ACS Style

Sánchez-Cruz, A.; Hernández-Fuentes, M.D.; Murillo-Gómez, C.; de la Rosa, E.J.; Hernández-Sánchez, C. Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa. Cells 2022, 11, 1621. https://doi.org/10.3390/cells11101621

AMA Style

Sánchez-Cruz A, Hernández-Fuentes MD, Murillo-Gómez C, de la Rosa EJ, Hernández-Sánchez C. Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa. Cells. 2022; 11(10):1621. https://doi.org/10.3390/cells11101621

Chicago/Turabian Style

Sánchez-Cruz, Alonso, María D. Hernández-Fuentes, Cayetana Murillo-Gómez, Enrique J. de la Rosa, and Catalina Hernández-Sánchez. 2022. "Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa" Cells 11, no. 10: 1621. https://doi.org/10.3390/cells11101621

APA Style

Sánchez-Cruz, A., Hernández-Fuentes, M. D., Murillo-Gómez, C., de la Rosa, E. J., & Hernández-Sánchez, C. (2022). Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa. Cells, 11(10), 1621. https://doi.org/10.3390/cells11101621

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa

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