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Cells
Volume 11
Issue 22
10.3390/cells11223666
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Review
Peer-Review Record

A Sweet Warning: Mucin-Type O-Glycans in Cancer

Cells 2022, 11(22), 3666; https://doi.org/10.3390/cells11223666
by Yuhan Zhang 1,†, Lingbo Sun 1,*,†, Changda Lei 2,†, Wenyan Li 1, Jiaqi Han 1, Jing Zhang 1 and Yuecheng Zhang 3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cells 2022, 11(22), 3666; https://doi.org/10.3390/cells11223666
Submission received: 21 October 2022 / Revised: 12 November 2022 / Accepted: 15 November 2022 / Published: 18 November 2022
(This article belongs to the Special Issue Glycobiology in Cancer: From Molecular Mechanisms to Therapeutic Opportunities)

Round 1

Reviewer 1 Report

This manuscript “A sweet warning: mucin-type O-glycans in cancer” is introducing the relationship between mucin-type glycans and diseases, especially cancer, from a view of biosynthesis based on a lot of literatures. This review is very comprehensive and represents a massive effort of authors. I believe this paper is acceptable, but it would be more beneficial to the readers if the authors would consider the following point.

Comment on Figure 1-3:

I am afraid that the figure legends or the main text contain very little explanation for all figures, so that the reader cannot decipher the contents of the figures. The figure should be understandable just by looking at it and the captions (legends), and also everything shown in the figure should be properly explained.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The review article is interesting and well written. My main criticism concern the lack of information about N-glycosylation of mucins and the occurence of shared carbohydrate antigens between N- and O-linked glycans in several glycoproteins including mucins. The authors should distinguish and make clear when mucin-type O-glycans are found on mucins and when on other glycoproteins.

Moreover, the wide list of roles of O-glycans and related glycosyltransferases and other enzymes should be organized and presented in a table where structures, enzymes, roles, and references are made easily recognizable by the readers.

Mispelling

page 9 line 376: ... Galbeta1-33[Fuc ... : change to 1-3[Fuc ..

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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