The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases
Abstract
:1. Introduction
2. Nrf-2 Redox Signaling in Cell Responses to Oxidative Stress
Nrf-2 Redox Signaling in Myocardium
3. Autophagy
3.1. Macro-Autophagy
3.2. Chaperon-Mediated Autophagy
3.3. Micro-Autophagy and Mitophagy
3.4. Autophagy in Myocardium
4. Interplay between Autophagy and Redox Signaling
5. Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases
5.1. Interplay between Nrf2 Redox Signaling and Autophagy in Ischemic Heart Disease
5.2. Interplay between Nrf2 Redox Signaling and Autophagy in Cardiomyopathies
5.3. Interplay between Nrf2 Redox Signaling and Autophagy in Heart Failure
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Disease | Model | Sample | Autophagy | Autophagy-Redox Signaling | Reference |
---|---|---|---|---|---|
Heart failure | TAC operation | Mice; Rat cardiac myocytes (H9c2) | Enhanced autophagosome formation and autophagic flux | Nrf2 increases autophagy-mediated clearance of ubiquitinated protein aggregates in cardiomyocytes | [30] |
TAC operation | Mice | - | When autophagy is intact, Nrf2 is required for cardiac remodeling. When autophagy is impaired, Nrf2 nuclear export is decreased and Nrf2-driven angiotensinogen transcription is increased, which can lead to cardiac dysfunction | [151,153] | |
TAC operation; patients with heart transplantation | Mice, human | Defective mitophagy | AMPK improves mitophagy via PINK-1 phosphorylation and decreases ROS formation | [154] | |
Ischemic heart disease | LAD ligation | Mice | - | Autophagy increases Nrf2 signaling activation, which leads to MI damage improvement | [8] |
I/R (LAD ligation) | Mice; NRCMs | Impaired mTORC-p62-Keap1-Nrf2 antioxidant defense system | Impaired mTORC-p62-Keap1-Nrf2 antioxidant defense system | [155] | |
I/R (LAD ligation) Urolithin B treatment | Rats | Urolithin B decreases autophagy by Akt/mTOR/ULK1 pathway | Urolithin B increases p62/Keap1/Nrf2 signaling pathway activation | [147] | |
Doxorubicin-induced cardiomyopathy | Doxorubicin treatment | Mice | Defective autophagy | P62-Keap1-Nrf2 activation leads to the positive regulation of oxidative stress and autophagy | [29,148] |
Cardiac laminopathy | Lamin C mutant | Drosophila melanogaster | Increased autophagy genes expression | Increased Nrf2 levels lead to autophagy inhibition by mTOR activation | [150] |
Diabetic cardiomyopathy | Type 1 diabetes | Mice | Defective autophagy | Autophagy inhibition leads to increased Nrf2 levels and thus to the progression of diabetic cardiomyopathy | [149] |
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Boťanská, B.; Dovinová, I.; Barančík, M. The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases. Cells 2022, 11, 1203. https://doi.org/10.3390/cells11071203
Boťanská B, Dovinová I, Barančík M. The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases. Cells. 2022; 11(7):1203. https://doi.org/10.3390/cells11071203
Chicago/Turabian StyleBoťanská, Barbora, Ima Dovinová, and Miroslav Barančík. 2022. "The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases" Cells 11, no. 7: 1203. https://doi.org/10.3390/cells11071203