Next Article in Journal
Myasthenia Gravis: An Acquired Interferonopathy?
Previous Article in Journal
Myosteatosis in Cirrhosis: A Review of Diagnosis, Pathophysiological Mechanisms and Potential Interventions
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 11
Issue 7
10.3390/cells11071217
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

by
Qiyan Yin
1,†,
Min Zheng
2,3,†,
Qianmei Luo
2,
Dewei Jiang
2,3,
Huifeng Zhang
4,* and
Ceshi Chen
2,5,6,*
1
Medical Faculty, Kunming University of Science and Technology, Kunming 650504, China
2
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650201, China
3
Kunming College of Life Sciences, The University of the Chinese Academy of Sciences, Kunming 650201, China
4
Department of Clinical Pharmacy, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China
5
Academy of Biomedical Engineering, Kunming Medical University, Kunming 650500, China
6
The Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2022, 11(7), 1217; https://doi.org/10.3390/cells11071217
Submission received: 23 February 2022 / Revised: 26 March 2022 / Accepted: 2 April 2022 / Published: 4 April 2022
Browse Figures
Versions Notes

Abstract

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.
Keywords: YB-1; transcription factor; cancer; RNA binding protein; therapeutic target YB-1; transcription factor; cancer; RNA binding protein; therapeutic target

Share and Cite

MDPI and ACS Style

Yin, Q.; Zheng, M.; Luo, Q.; Jiang, D.; Zhang, H.; Chen, C. YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy. Cells 2022, 11, 1217. https://doi.org/10.3390/cells11071217

AMA Style

Yin Q, Zheng M, Luo Q, Jiang D, Zhang H, Chen C. YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy. Cells. 2022; 11(7):1217. https://doi.org/10.3390/cells11071217

Chicago/Turabian Style

Yin, Qiyan, Min Zheng, Qianmei Luo, Dewei Jiang, Huifeng Zhang, and Ceshi Chen. 2022. "YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy" Cells 11, no. 7: 1217. https://doi.org/10.3390/cells11071217

APA Style

Yin, Q., Zheng, M., Luo, Q., Jiang, D., Zhang, H., & Chen, C. (2022). YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy. Cells, 11(7), 1217. https://doi.org/10.3390/cells11071217

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop