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Article
Peer-Review Record

Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis

Cells 2023, 12(13), 1736; https://doi.org/10.3390/cells12131736
by Sushma Marla 1, Sally Mortlock 1, Sohye Yoon 2, Joanna Crawford 2, Stacey Andersen 2, Michael D. Mueller 3, Brett McKinnon 1,3, Quan Nguyen 1 and Grant W. Montgomery 1,2,*
Reviewer 1:
Reviewer 2:
Reviewer 3:
Cells 2023, 12(13), 1736; https://doi.org/10.3390/cells12131736
Submission received: 9 May 2023 / Revised: 20 June 2023 / Accepted: 21 June 2023 / Published: 28 June 2023
(This article belongs to the Special Issue Molecular Advances and New Therapeutic Approaches in Endometriosis)

Round 1

Reviewer 1 Report


Comments for author File: Comments.pdf

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

Dear authors,

I read with great interest the manuscript, which falls within the aim of this Journal. In my honest opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors should clarify some points and improve the discussion, as suggested below. Authors should consider the following recommendations:

 In my opinion you have to improve the paper refering in the text to the fertility sparing treatments (FST) to the updated literature especially in pts that have to preserve their fetility for oncological reason and its implication.

Also about endometriosis I suggest you read and cite these interesting paper suggested below

Biomolecular and Genetic Prognostic Factors That Can Facilitate Fertility-Sparing Treatment (FST) Decision Making in Early Stage Endometrial Cancer (ES-EC): A Systematic Review

 

Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis

Fertility preservation in female cancer sufferers: (only) a moral obligation?

 

Minor editing of English language required

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 3 Report

Its a well planned, multi-platform integrative and systematically conducted research. The study provides clear evidence emphasizing importance of mapping cell-type specific transcriptional events for endometriosis. One advice is that if the authors provide a graphical abstract (summarizing the methodology), it will help the readers to understand the methodology adopted and the prominent findings.  

Author Response

Please see the attachment

Author Response File: Author Response.docx

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