Milk Fat Globule Epidermal Growth Factor VIII Fragment Medin in Age-Associated Arterial Adverse Remodeling and Arterial Disease
Abstract
:1. Introduction
2. MFG-E8 and Its Fragment Medin Expression during Age-Associated Inflammatory Remodeling
3. Medin Induces Vascular Cell Inflammation
3.1. EC Inflammation and Viability
3.2. VSMC Inflammation and Viability
4. Medin Remodels Extracellular Matrices
4.1. Amyloidosis
4.2. Elastolysis
4.3. Calcification
5. Medin Deposition Impairs Vascular Function
5.1. Arterial Endothelial Disorder and Dysfunction
5.2. Arterial Microstructure Disorder and Stiffening
6. Medin Deposition Is Involved in the Pathogenesis of Vascular Diseases
6.1. Arterial Aneurysms and Dissections
6.2. Temporal Arteritis
6.3. Vascular-Related Cognitive Impairment and Dementia
7. Concluding Remarks and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Amyloid Seed | Congo Red Staining | Electron Microscopy | Time to Form Amyloid Fibrils |
---|---|---|---|
Synthetic peptide | |||
Medin-aa 1–50 | + | + | 5–7 days |
Medin-aa 11–50 | + | + | 8–10 days |
Medin-aa 31–50 | + | + | 1 day |
Medin-aa 21–41 | + | + | Instantly |
Medin-aa 42–49 | + | + | 2–4 days |
Medin-aa 42–50 | + | + | Instantly |
Recombinant peptide Medin-aa 1–50 | + | + | Instantly |
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Wang, M.; McGraw, K.R.; Monticone, R.E. Milk Fat Globule Epidermal Growth Factor VIII Fragment Medin in Age-Associated Arterial Adverse Remodeling and Arterial Disease. Cells 2023, 12, 253. https://doi.org/10.3390/cells12020253
Wang M, McGraw KR, Monticone RE. Milk Fat Globule Epidermal Growth Factor VIII Fragment Medin in Age-Associated Arterial Adverse Remodeling and Arterial Disease. Cells. 2023; 12(2):253. https://doi.org/10.3390/cells12020253
Chicago/Turabian StyleWang, Mingyi, Kimberly R. McGraw, and Robert E. Monticone. 2023. "Milk Fat Globule Epidermal Growth Factor VIII Fragment Medin in Age-Associated Arterial Adverse Remodeling and Arterial Disease" Cells 12, no. 2: 253. https://doi.org/10.3390/cells12020253