Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy

Hsiao, Jen-Hsiang T.; Tanglay, Onur; Li, Anne A.; Strobbe, Aysha Y. G.; Kim, Woojin Scott; Halliday, Glenda M.; Fu, YuHong

doi:10.3390/cells12050739

Open AccessReview

Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy

by

Jen-Hsiang T. Hsiao

^†,

Onur Tanglay

^†,

Anne A. Li

,

Aysha Y. G. Strobbe

,

Woojin Scott Kim

,

Glenda M. Halliday

and

YuHong Fu

^*

Brain and Mind Centre, Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW 2050, Australia

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Cells 2023, 12(5), 739; https://doi.org/10.3390/cells12050739

Submission received: 9 December 2022 / Revised: 20 February 2023 / Accepted: 21 February 2023 / Published: 25 February 2023

(This article belongs to the Special Issue Advances in Neurogenesis: 2nd Edition)

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Abstract

Multiple system atrophy (MSA) is a debilitating movement disorder with unknown etiology. Patients present characteristic parkinsonism and/or cerebellar dysfunction in the clinical phase, resulting from progressive deterioration in the nigrostriatal and olivopontocerebellar regions. MSA patients have a prodromal phase subsequent to the insidious onset of neuropathology. Therefore, understanding the early pathological events is important in determining the pathogenesis, which will assist with developing disease-modifying therapy. Although the definite diagnosis of MSA relies on the positive post-mortem finding of oligodendroglial inclusions composed of α-synuclein, only recently has MSA been verified as an oligodendrogliopathy with secondary neuronal degeneration. We review up-to-date knowledge of human oligodendrocyte lineage cells and their association with α-synuclein, and discuss the postulated mechanisms of how oligodendrogliopathy develops, oligodendrocyte progenitor cells as the potential origins of the toxic seeds of α-synuclein, and the possible networks through which oligodendrogliopathy induces neuronal loss. Our insights will shed new light on the research directions for future MSA studies.

Keywords: alpha-synuclein; multiple system atrophy; neurodegeneration; oligodendrocyte; oligodendrocyte progenitor cell

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MDPI and ACS Style

Hsiao, J.-H.T.; Tanglay, O.; Li, A.A.; Strobbe, A.Y.G.; Kim, W.S.; Halliday, G.M.; Fu, Y. Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy. Cells 2023, 12, 739. https://doi.org/10.3390/cells12050739

AMA Style

Hsiao J-HT, Tanglay O, Li AA, Strobbe AYG, Kim WS, Halliday GM, Fu Y. Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy. Cells. 2023; 12(5):739. https://doi.org/10.3390/cells12050739

Chicago/Turabian Style

Hsiao, Jen-Hsiang T., Onur Tanglay, Anne A. Li, Aysha Y. G. Strobbe, Woojin Scott Kim, Glenda M. Halliday, and YuHong Fu. 2023. "Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy" Cells 12, no. 5: 739. https://doi.org/10.3390/cells12050739

APA Style

Hsiao, J.-H. T., Tanglay, O., Li, A. A., Strobbe, A. Y. G., Kim, W. S., Halliday, G. M., & Fu, Y. (2023). Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy. Cells, 12(5), 739. https://doi.org/10.3390/cells12050739

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Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy

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