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Article

The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma

by
Aneta Szudy-Szczyrek
1,*,
Radosław Mlak
2,
Marcin Mazurek
3,
Tomasz Krajka
4,
Sylwia Chocholska
1,
Paulina Bitkowska
1,
Marta Jutrzenka
5,
Michał Szczyrek
6,
Iwona Homa-Mlak
3,
Andrzej Krajka
7,
Teresa Małecka-Massalska
3 and
Marek Hus
1
1
Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-059 Lublin, Poland
2
Body Composition Research Laboratory, Department of Preclinical Sciences, Medical University of Lublin, 20-059 Lublin, Poland
3
Department of Human Physiology, Medical University of Lublin, 20-059 Lublin, Poland
4
Division of Mathematics, Department of Production Computerisation and Robotisation, Lublin University of Technology, 20-618 Lublin, Poland
5
Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland
6
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-059 Lublin, Poland
7
Institute of Computer Science, Maria Curie-Sklodowska University, 20-033 Lublin, Poland
*
Author to whom correspondence should be addressed.
Cells 2023, 12(7), 1029; https://doi.org/10.3390/cells12071029
Submission received: 11 January 2023 / Revised: 13 March 2023 / Accepted: 22 March 2023 / Published: 28 March 2023
(This article belongs to the Special Issue Molecular Mechanisms of Hematological Malignancies)
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Abstract

Background: The KIAA1524 gene encodes an oncoprotein, CIP2A, which inhibits the phosphorylation of the Akt kinase B, stabilizes the c-Myc protein, and, through that, promotes cancerogenesis. An increase in CIP2A expression has been observed in numerous solid tumors and hematologic malignancies, including multiple myeloma (MM). The aim of our study was to evaluate the clinical impact of the functional single nucleotide polymorphisms (SNP) of the KIAA1524 gene (rs2278911, 686C > T) in MM patients. Methods: The study group consisted of 128 patients with de novo MM. EDTA venous blood samples were collected prior to the treatment. The SNPs were analyzed by Real-Time PCR with the use of specific Taqman probes. Results: Multivariable analysis revealed that variables independently associated with shorter progression-free survival (PFS) included thrombocytopenia, delTP53 and IGH/CCND1 translocation and the TT genotype of the KIAA1524 gene (686C > T) (median PFS: 6 vs. 25 months; HR = 7.18). On the other hand, autologous haematopoietic stem cell transplantation (AHSCT) was related to a lower risk of early disease progression. Moreover, light chain disease, International Staging System (ISS) 3, poor performance status, hypoalbuminemia, IGH/FGFR3 translocation and the TT genotype of the KIAA1524 gene (686C > T) were independent prognostic factors associated with shorter overall survival (OS) (median OS: 8 vs. 45 months; HR = 7.08). Conclusion: The evaluation of the SNP 686C > T of the KIAA1524 gene could be used as a diagnostic tool in MM patients at risk of early disease progression and death.
Keywords: CIP2A; MYC; multiple myeloma; polymorphism; prognosis; molecular biomarkers CIP2A; MYC; multiple myeloma; polymorphism; prognosis; molecular biomarkers

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MDPI and ACS Style

Szudy-Szczyrek, A.; Mlak, R.; Mazurek, M.; Krajka, T.; Chocholska, S.; Bitkowska, P.; Jutrzenka, M.; Szczyrek, M.; Homa-Mlak, I.; Krajka, A.; et al. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma. Cells 2023, 12, 1029. https://doi.org/10.3390/cells12071029

AMA Style

Szudy-Szczyrek A, Mlak R, Mazurek M, Krajka T, Chocholska S, Bitkowska P, Jutrzenka M, Szczyrek M, Homa-Mlak I, Krajka A, et al. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma. Cells. 2023; 12(7):1029. https://doi.org/10.3390/cells12071029

Chicago/Turabian Style

Szudy-Szczyrek, Aneta, Radosław Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michał Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, and et al. 2023. "The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma" Cells 12, no. 7: 1029. https://doi.org/10.3390/cells12071029

APA Style

Szudy-Szczyrek, A., Mlak, R., Mazurek, M., Krajka, T., Chocholska, S., Bitkowska, P., Jutrzenka, M., Szczyrek, M., Homa-Mlak, I., Krajka, A., Małecka-Massalska, T., & Hus, M. (2023). The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma. Cells, 12(7), 1029. https://doi.org/10.3390/cells12071029

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