Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells

Desterke, Christophe; Francés, Raquel; Monge, Claudia; Marchio, Agnès; Pineau, Pascal; Mata-Garrido, Jorge

doi:10.3390/cells13191634

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Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells

by

Christophe Desterke

¹

,

Raquel Francés

^2,†

,

Claudia Monge

^3,†

,

Agnès Marchio

³,

Pascal Pineau

³

and

Jorge Mata-Garrido

^3,*

¹

Faculté de Médecine du Kremlin Bicêtre, Université Paris-Saclay and INSERM UMRS1310, 94270 Le Kremlin-Bicêtre, France

²

Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 75006 Paris, France

³

Institut Pasteur, Unité Organisation Nucléaire et Oncogenèse, INSERM U993, 75015 Paris, France

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Cells 2024, 13(19), 1634; https://doi.org/10.3390/cells13191634

Submission received: 30 August 2024 / Revised: 27 September 2024 / Accepted: 28 September 2024 / Published: 30 September 2024

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Abstract

Abstract: Cranial neural crest cells are implicated in multiple transcriptional events at the different stages of differentiation during development. The alteration of some transcription factors expressed during neural crest development, like PAX7, could be implicated in the etiology of face malformation in murine models. Epigenetic regulation has been shown to be an important mechanistic actor in the control of timing and the level of gene expression at different stages of neural crest development. During this work, we investigated the interconnection between epigenetics and transcription factors across a diversity of human development cranial neural crest cells. Across a diversity of neural cells from human developing cranial tissues, in accordance with their proliferation stage, an alternative balance of regulation between transcription factors and epigenetic factors was identified.

Keywords: craniofacial disease; epigenetics; neural crest; development; embryogenesis

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MDPI and ACS Style

Desterke, C.; Francés, R.; Monge, C.; Marchio, A.; Pineau, P.; Mata-Garrido, J. Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells. Cells 2024, 13, 1634. https://doi.org/10.3390/cells13191634

AMA Style

Desterke C, Francés R, Monge C, Marchio A, Pineau P, Mata-Garrido J. Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells. Cells. 2024; 13(19):1634. https://doi.org/10.3390/cells13191634

Chicago/Turabian Style

Desterke, Christophe, Raquel Francés, Claudia Monge, Agnès Marchio, Pascal Pineau, and Jorge Mata-Garrido. 2024. "Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells" Cells 13, no. 19: 1634. https://doi.org/10.3390/cells13191634

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Alternative Balance between Transcriptional and Epigenetic Regulation during Developmental Proliferation of Human Cranial Neural Crest Cells

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