Magnetic-Assisted Treatment of Liver Fibrosis
Abstract
:1. Introduction
1.1. Liver Fibrosis
1.2. Roles of Different Hepatic Cell Types in Liver Fibrosis
1.3. Current Clinical Trials on Liver Fibrosis
2. Theoretical Background of Magnetism
2.1. Magnetic Nanomedicines
2.1.1. Methods for Synthesis of Magnetic Nanomedicines
2.1.2. Clinical Use and Further Perspectives Iron Oxide
2.1.3. Magnetic Hybrid Nanomaterials
2.2. Magnetic Materials in Drug Delivery
2.2.1. Magnetic-Assisted Medical Applications
2.2.2. Selective Targeting of Hepatic Stellate Cells—Mission Impossible?
Author Contributions
Funding
Conflicts of Interest
References
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Molecular Target | Compound | Effect |
---|---|---|
Apoptosis signal-regulating kinase 1 (ASK1) | Selonsertib (GS-4997) | oral bioavailable inhibitor of ASK1, thereby preventing the production of inflammatory and fibrotic acting cytokines |
Hepatic metabolism | Obeticholic acid | synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR) |
Elafibranor | Orally administered drug acting on the 3 sub-types of PPAR (PPARα, PPARγ, PPARδ) | |
Tropifexor | Investigational drug which acts as an agonist of the farnesoid X nuclear receptor (FXR) | |
Cilofexor (GS-9674) | agonist of the farnesoid X nuclear receptor (FXR) which improves cholestasis and liver injury | |
AKN-083 | farnesoid X receptor (FXR) agonist | |
INT-767 | a dual agonist targeting the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (GPBAR1) | |
Aramchol | An orally active fatty acid bile acid conjugate that inhibits stearoyl coenzyme A desaturase 1 (SCD1) | |
Saroglitazar | Agonist of PPARα (and PPARγ) | |
Lanifibranor | Orally administered drug acting on the 3 sub-types of PPAR (PPARα, PPARγ, PPARδ) | |
Firsocostat (GS-0976) | Liver-targeted acetyl-CoA carboxylase (ACC) inhibitor | |
PF-05221304 | Liver-targeted acetyl-CoA carboxylase (ACC) inhibitor | |
Chemokine receptors | Cenicriviroc | blocks the chemokine receptors CC chemokine receptor 2 (CCR2) and CCR5 |
Caspases | Emricasan | Prevents cells death by inhibition of caspases |
VX-166 | The drug has anti-apoptotic activity and prevents release of interleukins | |
Nivocasan (GS-9450) | hepatoprotective activity preventing fibrosis and apoptosis | |
Fibroblast growth factor 21 (FGF21) | Pegbelfermin (BMS-986036) | PEGylated FGF21 analogue that improves metabolic parameters |
Fibroblast growth factor 19 (FGF19) | Aldafermin (NGM282) | Synthetic FGF19 analogue preventing hepatic fat accumulation and liver damage |
Glucagon-like peptide-1 receptor | Liraglutide | GLP-1 receptor agonist triggering insulin synthesis |
Semaglutide | GLP-1 receptor agonist triggering insulin synthesis |
Role of MNP1 | Area of Biomedical Application | Literature |
---|---|---|
Binding-mediated cell capturing | Cell isolation and separation | [141,143,144,145] |
Cell and tissue engineering | [146,147,148] | |
Cell patterning and concentration | [149,150,151,152,153] | |
Mechanical cell control | Low-frequency magnetic field for cell destruction and induction of apoptosis | [78,155,156] |
Differentiation of stem cells, modulation of cell division and motility | [157,158,159] | |
Fundamental study of macromolecules and cell‘s mechanical properties | [160,161] | |
Drug delivery | Magnetic fluid hyperthermia of cancer | [135,162,163] |
On-demand release of drugs via thermosensitive polymers or azo molecules from hybrid nanoplatforms | [133,164,165] | |
Targeting or delivery of drug or genes immobilized on surfaces | [166,167,168,169] | |
Imaging applications | Reduction of T1 and T2 relaxation time of the water protons for the MRI-contrast | [66,124,170] |
Imaging and detection via a non-linear magnetic signal | [172,173] | |
Improved detection of magnetic signals, imaging of liver fibrosis | [174,175] |
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Levada, K.; Omelyanchik, A.; Rodionova, V.; Weiskirchen, R.; Bartneck, M. Magnetic-Assisted Treatment of Liver Fibrosis. Cells 2019, 8, 1279. https://doi.org/10.3390/cells8101279
Levada K, Omelyanchik A, Rodionova V, Weiskirchen R, Bartneck M. Magnetic-Assisted Treatment of Liver Fibrosis. Cells. 2019; 8(10):1279. https://doi.org/10.3390/cells8101279
Chicago/Turabian StyleLevada, Kateryna, Alexander Omelyanchik, Valeria Rodionova, Ralf Weiskirchen, and Matthias Bartneck. 2019. "Magnetic-Assisted Treatment of Liver Fibrosis" Cells 8, no. 10: 1279. https://doi.org/10.3390/cells8101279
APA StyleLevada, K., Omelyanchik, A., Rodionova, V., Weiskirchen, R., & Bartneck, M. (2019). Magnetic-Assisted Treatment of Liver Fibrosis. Cells, 8(10), 1279. https://doi.org/10.3390/cells8101279