The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Animals
2.2. Cardiocirculatory Death Induction
2.3. Surgical Procedure of Liver Transplantation
2.4. Experimental Design
2.5. Biochemical Assays
2.6. Western Blotting
2.7. Reverse Transcription and Quantitative Polymerase Chain Reaction
2.8. Liver and Intestine Histology
2.9. Immunohistochemistry
2.10. Statistics
3. Results
3.1. Role of FGF15 in Recipients of Non-Steatotic and Steatotic Liver Grafts from DCDs
3.2. FGF15 Levels in Intestine and Plasma in LT from DCDs
3.3. The Effects of FGF15 on the BA Synthesis Pathway in LT from DCDs
3.4. The Effect of FGF15 on the Hippo/YAP Signaling Pathway in Liver Grafts from DCDs after LT
3.5. FGF15 and Related Signaling Pathways in Liver Grafts from DCDs before Procurement
4. Discussion
Author Contributions
Funding
Conflicts of Interest
Abbreviations
ALT | Alanine aminotransferase |
AST | Aspartate aminotransferase |
BAs | Bile acids |
BLC | B lymphocyte chemoattractant |
CD | Cardiocirculatory death |
COX-2 | Cyclooxygenase 2 |
Ctgf | Connective tissue growth factor |
CYP7A1 | Cytochrome P450 7A1 |
CYP27A1 | Cytochrome P450 27A1 |
DAB | Diaminobenzidine |
DCDs | Donors after cardiacirculatory death |
ERK1/2 | Extracellular signal-regulated protein kinase |
FGF15 | Fibroblast growth factor 15 |
FGF19 | Fibroblast growth factor 19 |
FGFR4 | Fibroblast growth factor receptor 4 |
G-CSF | Granulocyte colony stimulating factor |
GM-CSF | Granulocyte macrophage colony stimulating factor |
I/R | Ischemia-reperfusion |
ICAM-1 | Intercellular adhesion molecule-1 |
IP-10 | Interferon gamma-induced protein 10 |
IQGAP1 | IQ motif containing GTPase activating protein 1 |
I-TAC | Interferon-inducible T-cell alpha chemoattractant |
KC | Chemokines as keratinocyte chemoattractant |
LATS1/2 | Large tumor suppressor 1 and 2 |
LIX | LPS-induced CXC chemokine |
Ln | Lean |
LT | Liver transplantation |
MCP | Monocyte chemoattractant protein |
MIP | Macrophage inflammatory protein |
MDA | Malondialdehyde |
MPO | Myeloperoxidase |
MST1/2 | Mammalian sterile-20 kinase 1 and 2 |
NASH | Non-alcoholic steatohepatitis |
Ob | Obese |
OCT | Optimal cutting temperature |
PAI-1 | Plasminogen activator inhibitor-1 |
PCNA | Proliferating cell nuclear antigen |
PKC | Protein kinase C |
RANTES | Regulated upon activation, normal T cell expressed and presumably secreted |
SR-PSOX | Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein |
uPAR | Urokinase plasminogen activator receptor |
UW | University of wisconsin |
VCAM-1 | Vascular cell adhesion molecule-1 |
YAP | Yes-associated protein |
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Avalos-de León, C.G.; Jiménez-Castro, M.B.; Cornide-Petronio, M.E.; Gulfo, J.; Rotondo, F.; Gracia-Sancho, J.; Casillas-Ramírez, A.; Peralta, C. The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death. Cells 2019, 8, 1640. https://doi.org/10.3390/cells8121640
Avalos-de León CG, Jiménez-Castro MB, Cornide-Petronio ME, Gulfo J, Rotondo F, Gracia-Sancho J, Casillas-Ramírez A, Peralta C. The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death. Cells. 2019; 8(12):1640. https://doi.org/10.3390/cells8121640
Chicago/Turabian StyleAvalos-de León, Cindy G., Mónica B. Jiménez-Castro, María Eugenia Cornide-Petronio, José Gulfo, Floriana Rotondo, Jordi Gracia-Sancho, Araní Casillas-Ramírez, and Carmen Peralta. 2019. "The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death" Cells 8, no. 12: 1640. https://doi.org/10.3390/cells8121640