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Review

Nuclear Organization in Stress and Aging

by
Raquel Romero-Bueno
†,
Patricia de la Cruz Ruiz
†,
Marta Artal-Sanz
,
Peter Askjaer
* and
Agnieszka Dobrzynska
*
Andalusian Center for Developmental Biology (CABD), Consejo Superior de Investigaciones Científicas/Junta de Andalucia/Universidad Pablo de Olavide, 41013 Seville, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2019, 8(7), 664; https://doi.org/10.3390/cells8070664
Submission received: 28 May 2019 / Revised: 23 June 2019 / Accepted: 25 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Nuclear Organisation)
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Abstract

The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by the nuclear envelope, which plays a prominent role in the structural organization of the cell, including nucleocytoplasmic communication, chromatin positioning, and gene expression. Alterations in nuclear composition and function are eminently pronounced upon stress and during premature and physiological aging. These alterations are often accompanied by epigenetic changes in histone modifications. We review, here, the role of nuclear envelope proteins and histone modifiers in the 3-dimensional organization of the genome and the implications for gene expression. In particular, we focus on the nuclear lamins and the chromatin-associated protein BAF, which are linked to Hutchinson–Gilford and Nestor–Guillermo progeria syndromes, respectively. We also discuss alterations in nuclear organization and the epigenetic landscapes during normal aging and various stress conditions, ranging from yeast to humans.
Keywords: chromatin; epigenetics; HGPS; laminopathies; longevity; mitochondrial unfolded protein response; progeria; NGPS; transcription chromatin; epigenetics; HGPS; laminopathies; longevity; mitochondrial unfolded protein response; progeria; NGPS; transcription

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MDPI and ACS Style

Romero-Bueno, R.; Ruiz, P.d.l.C.; Artal-Sanz, M.; Askjaer, P.; Dobrzynska, A. Nuclear Organization in Stress and Aging. Cells 2019, 8, 664. https://doi.org/10.3390/cells8070664

AMA Style

Romero-Bueno R, Ruiz PdlC, Artal-Sanz M, Askjaer P, Dobrzynska A. Nuclear Organization in Stress and Aging. Cells. 2019; 8(7):664. https://doi.org/10.3390/cells8070664

Chicago/Turabian Style

Romero-Bueno, Raquel, Patricia de la Cruz Ruiz, Marta Artal-Sanz, Peter Askjaer, and Agnieszka Dobrzynska. 2019. "Nuclear Organization in Stress and Aging" Cells 8, no. 7: 664. https://doi.org/10.3390/cells8070664

APA Style

Romero-Bueno, R., Ruiz, P. d. l. C., Artal-Sanz, M., Askjaer, P., & Dobrzynska, A. (2019). Nuclear Organization in Stress and Aging. Cells, 8(7), 664. https://doi.org/10.3390/cells8070664

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