The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration
Abstract
:1. Why Is Serine Important to the Entire Retina?
2. Why Does the Retina Need to Synthesize Serine?
De Novo Serine Synthesis in Müller Cells
3. Serine Homeostasis Plays an Important Role in the Maintenance of the Retina
3.1. Serine and Sphingolipids
3.2. Serine and RPE Phagocytosis
3.3. The Role of D-Serine
3.4. Serine and Epigenetic Regulation
4. Serine Is an Anti-Oxidant and Mediator of Inflammation
5. Consequences of Aberrations in Serine Metabolism
6. Retinal Degeneration and Dysregulated Serine Metabolism
6.1. Inherited Retinal Degeneration
6.2. Diabetic Retinopathy
7. Novel Insights: Macular Telangiectasia
8. Concluding Remarks
Funding
Conflicts of Interest
References
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Sinha, T.; Ikelle, L.; Naash, M.I.; Al-Ubaidi, M.R. The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration. Cells 2020, 9, 674. https://doi.org/10.3390/cells9030674
Sinha T, Ikelle L, Naash MI, Al-Ubaidi MR. The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration. Cells. 2020; 9(3):674. https://doi.org/10.3390/cells9030674
Chicago/Turabian StyleSinha, Tirthankar, Larissa Ikelle, Muna I. Naash, and Muayyad R. Al-Ubaidi. 2020. "The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration" Cells 9, no. 3: 674. https://doi.org/10.3390/cells9030674