Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics
Abstract
:1. Introduction
- MP structure and function in ECM
- MPs in cell signaling
- MPs in cancer
- MPs in central nervous system and neurodegenerative diseases
- MPs in cardiovascular diseases
- MPs in fibrosis and other diseases
- MMP inhibition for developing therapeutics
- MMP-responsive drugs and drug delivery tools
- Conclusion and future directions
2. MP Structure and Function in ECM
3. MMP Regulation in the ECM
4. MPs and Their Inhibitors in Cell Signaling
5. MPs in Cancer
6. MPs in Central Nervous System and Neurodegenerative Diseases
7. MPs in Cardiovascular Diseases
8. MPs in Fibrosis and Other Diseases
9. MMP Inhibition for Developing Therapeutics
9.1. Small Molecules
9.2. Peptides
9.3. Protein-Based MP Inhibitors
9.3.1. Antibodies
9.3.2. TIMPs
10. MMP-Activated Drugs and Drug Delivery Tools
10.1. MMP-Responsive Prodrugs
10.2. MMP-Responsive Hydrogels
10.3. MMP-Responsive Nanoparticles
11. Discussion and Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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MMP Inhibitor | Type | Clinical Trial | Specificity | Reference |
---|---|---|---|---|
Periostat (doxycycline hydraxate) | Small molecule | FDA approved | Broad spectrum | [222,223] |
IImostat; GM6001(Hydroxamate derivative) | Small molecule | Phase I, II | MMP-1, -2, -9 | [224] |
Marimastat (BB-2516) | Small molecule | Phase II | Broad spectrum | [225] |
Prinomastat (AG-3340) | Small molecule | Phase III | MMP-1, -2, -9 | [226] |
Batimastat (BB-94) | peptide | Phase I | Broad spectrum | [227,228] |
GA-5745/andecaliximab | mAb | Phase I, II, III | MMP-9 | [221,229,230] |
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Raeeszadeh-Sarmazdeh, M.; Do, L.D.; Hritz, B.G. Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics. Cells 2020, 9, 1313. https://doi.org/10.3390/cells9051313
Raeeszadeh-Sarmazdeh M, Do LD, Hritz BG. Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics. Cells. 2020; 9(5):1313. https://doi.org/10.3390/cells9051313
Chicago/Turabian StyleRaeeszadeh-Sarmazdeh, Maryam, Linh D. Do, and Brianne G. Hritz. 2020. "Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics" Cells 9, no. 5: 1313. https://doi.org/10.3390/cells9051313
APA StyleRaeeszadeh-Sarmazdeh, M., Do, L. D., & Hritz, B. G. (2020). Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics. Cells, 9(5), 1313. https://doi.org/10.3390/cells9051313