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Cells
Volume 9
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10.3390/cells9061344
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Article

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

by
Hyun Ah Oh
1,†,
Jihye Kwak
1,†,
Beom Joon Kim
2,
Hye Jin Jin
1,
Won Seok Park
3,
Soo Jin Choi
1,
Wonil Oh
1 and
Soyoun Um
1,*
1
Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea
2
Department of Dermatology, Chung-Ang University College of Medicine, Seoul 06974, Korea
3
Aesthetic Research Team, Amore Pacific Corporation Research and Development Center, Yongin 17074, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2020, 9(6), 1344; https://doi.org/10.3390/cells9061344
Submission received: 30 March 2020 / Revised: 26 May 2020 / Accepted: 27 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Stem Cell Therapy: Wound Healing and Skin Regeneration)
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Abstract

Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-β1 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related β-catenin and p-GSK-3β [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.
Keywords: hair growth; conditioned media; VEGF; MIF; human mesenchymal stromal cells; androgenic alopecia hair growth; conditioned media; VEGF; MIF; human mesenchymal stromal cells; androgenic alopecia

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MDPI and ACS Style

Oh, H.A.; Kwak, J.; Kim, B.J.; Jin, H.J.; Park, W.S.; Choi, S.J.; Oh, W.; Um, S. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth. Cells 2020, 9, 1344. https://doi.org/10.3390/cells9061344

AMA Style

Oh HA, Kwak J, Kim BJ, Jin HJ, Park WS, Choi SJ, Oh W, Um S. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth. Cells. 2020; 9(6):1344. https://doi.org/10.3390/cells9061344

Chicago/Turabian Style

Oh, Hyun Ah, Jihye Kwak, Beom Joon Kim, Hye Jin Jin, Won Seok Park, Soo Jin Choi, Wonil Oh, and Soyoun Um. 2020. "Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth" Cells 9, no. 6: 1344. https://doi.org/10.3390/cells9061344

APA Style

Oh, H. A., Kwak, J., Kim, B. J., Jin, H. J., Park, W. S., Choi, S. J., Oh, W., & Um, S. (2020). Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth. Cells, 9(6), 1344. https://doi.org/10.3390/cells9061344

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