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Volume 9
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Review

How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

by
Raquel Sales-Gil
and
Paola Vagnarelli
*
College of Health and Life Science, Brunel University London, London UB8 3PH, UK
*
Author to whom correspondence should be addressed.
Cells 2020, 9(6), 1460; https://doi.org/10.3390/cells9061460
Submission received: 19 May 2020 / Revised: 10 June 2020 / Accepted: 11 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Heterochromatin Formation and Function)
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Abstract

Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure. Besides the well-established phosphorylation of histone H3 Ser10 that has been shown to modulate HP1 binding to chromatin, several studies have recently highlighted the importance of HP1 post-translational modifications and additional epigenetic features for the modulation of HP1-chromatin binding ability and heterochromatin formation. In this review, we summarize the recent literature of HP1 post-translational modifications that have contributed to understand how heterochromatin is formed, regulated and maintained.
Keywords: heterochromatin; HP1; post-translational modifications; centromeres heterochromatin; HP1; post-translational modifications; centromeres

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MDPI and ACS Style

Sales-Gil, R.; Vagnarelli, P. How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance. Cells 2020, 9, 1460. https://doi.org/10.3390/cells9061460

AMA Style

Sales-Gil R, Vagnarelli P. How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance. Cells. 2020; 9(6):1460. https://doi.org/10.3390/cells9061460

Chicago/Turabian Style

Sales-Gil, Raquel, and Paola Vagnarelli. 2020. "How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance" Cells 9, no. 6: 1460. https://doi.org/10.3390/cells9061460

APA Style

Sales-Gil, R., & Vagnarelli, P. (2020). How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance. Cells, 9(6), 1460. https://doi.org/10.3390/cells9061460

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