Annexin A2 in Inflammation and Host Defense
Abstract
:1. Introduction
2. Annexin A2 and Infection
3. Annexin A2 and Regulation of Vascular Integrity
4. Annexin A2 and Recruitment of Inflammatory Cells
5. Annexin A2 in Inflammasome Dynamics
6. Annexin A2 and Macroautophagy
7. Annexin A2 in Angiogenesis
8. Annexin A2 and Tumor Progression
9. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Pathogen | AnxA2 role | References |
---|---|---|
Bacteria | ||
Anti-Inflammatory Actions | ||
Klebsiella pneumoniae | Reduced cytokine response | [24] |
Pro-Inflammatory Actions | ||
Pseudomonas aeruginosa | Plasma membrane adhesion | [32] |
Escherichia coli | Plasma membrane adhesion | [33,38] |
Salmonella typhimurium | Host cell invasion | [34] |
Rickettsia australis | Plasma membrane adhesion | [35] |
Fungus | ||
Anti-Inflammatory Actions | ||
Cryptococcus neoformans | Phagocytosis and exocytosis | [25] |
Pro-Inflammatory Actions | ||
none reported | --- | --- |
Virus | ||
Anti-Inflammatory Actions | ||
Human Papillomavirus | Attachment and intracellular trafficking | [40,41,42] |
Pro-Inflammatory Actions | ||
none reported | --- | --- |
Action | Model System | Result in Anxa2-/- | References |
---|---|---|---|
Infection | Klebsiella pneumonia | Increased mortality | [24] |
Cryptococcal pneumonia | Increased mortality and enhanced inflammatory response | [25] | |
Rickettsia australis | Increased bacteria in blood and reduced adhesion to vascular endothelial cells | [35] | |
Vascular integrity | Hypoxia | Increased vascular leak in lungs and skin | [47] |
Tracer injection in embryonic mice | Increased leakage of 10-kDA-dextran | [48] | |
Inflammasome Dynamics | Anaplasmaphagocytophilum peritonitis | Increased bacterial load, splenomegaly, and cytopenias | [55] |
Macroautophagy | Starvation-induced autophagy | Abrogation of autophagosome biogenesis | [66] |
Pseudomonasaeruginosa pneumonia | Reduced survival, increased bacterial dissemination, and blunted autophagy | [68] | |
Angiogenesis | Cornea pocket assay | Reduced growth factor induced neoangiogenesis | [75] |
Matrigel implant assay | Reduced growth factor induced neoangiogenesis | [78] | |
Oxygen-induced retinopathy | Reduced angiogenesis and fibrinolysis with fibrin accumulation | [77] | |
Tumor progression | Intracerebral glioma cell implantation | Increased tumor size and reduced vascularity | [88] |
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Dallacasagrande, V.; Hajjar, K.A. Annexin A2 in Inflammation and Host Defense. Cells 2020, 9, 1499. https://doi.org/10.3390/cells9061499
Dallacasagrande V, Hajjar KA. Annexin A2 in Inflammation and Host Defense. Cells. 2020; 9(6):1499. https://doi.org/10.3390/cells9061499
Chicago/Turabian StyleDallacasagrande, Valentina, and Katherine A. Hajjar. 2020. "Annexin A2 in Inflammation and Host Defense" Cells 9, no. 6: 1499. https://doi.org/10.3390/cells9061499