Macrophage Modification Strategies for Efficient Cell Therapy

Poltavets, Anastasiya S.; Vishnyakova, Polina A.; Elchaninov, Andrey V.; Sukhikh, Gennady T.; Fatkhudinov, Timur Kh.

doi:10.3390/cells9061535

Open AccessReview

Macrophage Modification Strategies for Efficient Cell Therapy

by

Anastasiya S. Poltavets

¹,

Polina A. Vishnyakova

^1,2,*

,

Andrey V. Elchaninov

^1,3

,

Gennady T. Sukhikh

¹ and

Timur Kh. Fatkhudinov

^2,4

¹

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, Russia

²

Department of Histology, Cytology and Embryology, Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow 117198, Russia

³

Department of Histology, Pirogov Russian National Research Medical University, Ministry of Healthcare of The Russian Federation, 1 Ostrovitianov Street, Moscow 117997, Russia

⁴

Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow 117418, Russia

^*

Author to whom correspondence should be addressed.

Cells 2020, 9(6), 1535; https://doi.org/10.3390/cells9061535

Submission received: 23 April 2020 / Revised: 17 June 2020 / Accepted: 22 June 2020 / Published: 24 June 2020

(This article belongs to the Special Issue Leukocytes in Inflammation, Resolution of Inflammation, Autoimmune Diseases and Cancer)

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Abstract

Macrophages, important cells of innate immunity, are known for their phagocytic activity, capability for antigen presentation, and flexible phenotypes. Macrophages are found in all tissues and therefore represent an attractive therapeutic target for the treatment of diseases of various etiology. Genetic programming of macrophages is an important issue of modern molecular and cellular medicine. The controllable activation of macrophages towards desirable phenotypes in vivo and in vitro will provide effective treatments for a number of inflammatory and proliferative diseases. This review is focused on the methods for specific alteration of gene expression in macrophages, including the controllable promotion of the desired M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes in certain pathologies or model systems. Here we review the strategies of target selection, the methods of vector delivery, and the gene editing approaches used for modification of macrophages.

Keywords: macrophages; cell therapy; genetic modification; inflammation; polarization

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MDPI and ACS Style

Poltavets, A.S.; Vishnyakova, P.A.; Elchaninov, A.V.; Sukhikh, G.T.; Fatkhudinov, T.K. Macrophage Modification Strategies for Efficient Cell Therapy. Cells 2020, 9, 1535. https://doi.org/10.3390/cells9061535

AMA Style

Poltavets AS, Vishnyakova PA, Elchaninov AV, Sukhikh GT, Fatkhudinov TK. Macrophage Modification Strategies for Efficient Cell Therapy. Cells. 2020; 9(6):1535. https://doi.org/10.3390/cells9061535

Chicago/Turabian Style

Poltavets, Anastasiya S., Polina A. Vishnyakova, Andrey V. Elchaninov, Gennady T. Sukhikh, and Timur Kh. Fatkhudinov. 2020. "Macrophage Modification Strategies for Efficient Cell Therapy" Cells 9, no. 6: 1535. https://doi.org/10.3390/cells9061535

APA Style

Poltavets, A. S., Vishnyakova, P. A., Elchaninov, A. V., Sukhikh, G. T., & Fatkhudinov, T. K. (2020). Macrophage Modification Strategies for Efficient Cell Therapy. Cells, 9(6), 1535. https://doi.org/10.3390/cells9061535

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Macrophage Modification Strategies for Efficient Cell Therapy

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