Integrative Map of HIF1A Regulatory Elements and Variations
Abstract
:1. Introduction
2. Materials and Methods
3. Results and Discussion
3.1. Characteristics of the HIF1A Gene
3.2. Genetic Variability of the HIF1A Gene
3.3. A Map of HIF Regulatory Elements
3.3.1. HIF Target Genes
3.3.2. Upstream Regulation of HIF1A Signaling
3.3.3. Epigenomics
3.3.4. MicroRNA Regulation
3.3.5. Protein Interactions
3.3.6. Post-Translational Modifications (PTMs)
3.4. Association of HIF1A with Diseases
3.5. Future Developments
- Update of the review on associations between HIF genes and diseases.
- Development of a catalog of regulatory elements regulating HIF1A expression (upstream regulators).
- Update of the catalog of reported HIF1A target genes (downstream signaling cascades).
- Identification of novel HIF1A target genes.
- Multi-omics view in understanding HIF1A regulation, including genomics–DNA level, transcriptomics–RNA level, proteomics, glycomics, epigenomics, and miRNomics.
- Identification of therapeutic strategies targeting the HIF signaling pathway for therapy in various diseases, including cancer.
- Analysis of potential functional effect of polymorphisms located within sites of HIF1A protein hydroxylation and methylation.
4. Conclusions
Supplementary Materials
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Kunej, T. Integrative Map of HIF1A Regulatory Elements and Variations. Genes 2021, 12, 1526. https://doi.org/10.3390/genes12101526
Kunej T. Integrative Map of HIF1A Regulatory Elements and Variations. Genes. 2021; 12(10):1526. https://doi.org/10.3390/genes12101526
Chicago/Turabian StyleKunej, Tanja. 2021. "Integrative Map of HIF1A Regulatory Elements and Variations" Genes 12, no. 10: 1526. https://doi.org/10.3390/genes12101526
APA StyleKunej, T. (2021). Integrative Map of HIF1A Regulatory Elements and Variations. Genes, 12(10), 1526. https://doi.org/10.3390/genes12101526