The Ehlers–Danlos Syndromes against the Backdrop of Inborn Errors of Metabolism
Round 1
Reviewer 1 Report
It was a pleasure to review this very well written and comprehensive review article about Ehlers-Danlos syndrome and an interesting parallel with a subset of inborn errors of metabolism disorders. The structure of the article reflects the clinical, histological and molecular aspects of EDS, with up-to-date experimental evidence and highlighting the unknown elements. This will be of great interest to both clinicians and researchers.
Reviewer 2 Report
Van Damme et al presents a very comprehensive overview of Ehlers-Danlos syndrome, including clinical, genetic and molecular findings.
The review is very well-written, tables are useful also in a clinical setting.
I could wish for a few closing remarks at the end of the paper, but otherwise I have no commonts.