Next Article in Journal
Genome-Wide Analysis of the LRR-RLP Gene Family in a Wild Banana (Musa acuminata ssp. malaccensis) Uncovers Multiple Fusarium Wilt Resistance Gene Candidates
Next Article in Special Issue
Identification of Two Novel EPOR Gene Variants in Primary Familial Polycythemia: Case Report and Literature Review
Previous Article in Journal
Rare and Common Variants Uncover the Role of the Atria in Coarctation of the Aorta
Previous Article in Special Issue
The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Genes
Volume 13
Issue 4
10.3390/genes13040637
Review Report
genes-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Genetic Background of Polycythemia Vera

Genes 2022, 13(4), 637; https://doi.org/10.3390/genes13040637
by Mathilde Regimbeau 1,†, Romain Mary 1,2,†, François Hermetet 1,‡ and François Girodon 1,3,4,5,*,‡
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Genes 2022, 13(4), 637; https://doi.org/10.3390/genes13040637
Submission received: 2 March 2022 / Revised: 25 March 2022 / Accepted: 26 March 2022 / Published: 2 April 2022
(This article belongs to the Special Issue Genetics and Genomics of Erythrocytosis)

Round 1

Reviewer 1 Report

In their paper the authors present a comprehensive catalogue of genes that are mutated in polycythemia vera (PV) with detailed information about their function and prevalence. These genes are grouped together depending on their function, associated pathway and molecular mechanism. The review brings all this information together in one source which will be a valuable reference when reviewing the genetic landscape of PV by next generation sequencing.

  1. Using all the information provided about the genetic landscape of PV can the authors develop the paper further to provide insights such as
    1. Is there any associations between genes of the same of different pathways?
    2. Are there genes that are mutually exclusive?
  2. Is it possible for the authors for provide visual representation of the mutated genes associated with JAK2 either using a Venn diagram or a Circos plat?
  3. Would it be possible to summarise the overview of the genetic associations or absences in an additional section?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled “Genetic Background of Polycythemia Vera” is a review article on the genetic mutations in Polycythemia Vera. The goal of the current review is to collect the available literature regarding the canonical and non-canonical mutations together with their clinical significance. This article provides an useful information for clinical hematologists. Anyway, I think that the Authors should add a paragraph about the molecular analysis describing the standardized techniques and more sensitive detection methods and comment them.

 

Author Response

Please see the attachment. 

Author Response File: Author Response.docx

Back to TopTop