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Volume 14
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Review

The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response

by
Ekaterina A. Belousova
* and
Olga I. Lavrik
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Genes 2023, 14(1), 112; https://doi.org/10.3390/genes14010112
Submission received: 25 November 2022 / Revised: 22 December 2022 / Accepted: 23 December 2022 / Published: 30 December 2022
(This article belongs to the Special Issue DNA Replication/Repair, and the DNA Damage Response in Human Disease)
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Abstract

The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-acid complexes, whose minimal structural unit is the nucleosome. After the damage to genomic DNA, repair proteins need to gain access directly to the lesion; therefore, the initiation of the DNA damage response inevitably leads to local chromatin reorganisation. This review focuses on the possible involvement of PARP1, as well as proteins acting nucleosome compaction, linker histone H1 and non-histone chromatin protein HMGB1. The polymer of ADP-ribose is considered the main regulator during the development of the DNA damage response and in the course of assembly of the correct repair complex.
Keywords: nucleosome core particle; DNA damage response; PARP1; PAR; histone H1; HMGB1 nucleosome core particle; DNA damage response; PARP1; PAR; histone H1; HMGB1
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MDPI and ACS Style

Belousova, E.A.; Lavrik, O.I. The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response. Genes 2023, 14, 112. https://doi.org/10.3390/genes14010112

AMA Style

Belousova EA, Lavrik OI. The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response. Genes. 2023; 14(1):112. https://doi.org/10.3390/genes14010112

Chicago/Turabian Style

Belousova, Ekaterina A., and Olga I. Lavrik. 2023. "The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response" Genes 14, no. 1: 112. https://doi.org/10.3390/genes14010112

APA Style

Belousova, E. A., & Lavrik, O. I. (2023). The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response. Genes, 14(1), 112. https://doi.org/10.3390/genes14010112

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