Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics
Abstract
:1. Introduction
2. Complex and Monogenic Traits
3. The Role and Limitations of Genome-Wide Association Studies
4. Practical Application of Combined Genome Variants for Complex Traits
5. Omnigenic Model Implementation
6. Biological Pathways for Behaviour Traits
7. Core Genes of Behaviour
8. Core Genes: Ethnic and Gender Perspectives
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Behaviour Trait | Core Genes | Genome Variants | References |
---|---|---|---|
Alcohol Use | ADH1B, ADH1C, ALDH2 | rs1229984, rs698, rs671 | [30,31,44] |
Smoking | CHRNA5, CHRNA3, CHRNB4 | rs16969968, rs1051730 | [38,45,46,47] |
Drug Use | DRD2, OPRM1, ABCB1 | rs1800497, rs1799971, rs1045642 | [48,49,50] |
Stress | FKBP5, CRHR1, NR3C1 | rs1360780, rs110402, rs6195 | [51,52,53] |
Anxiety | SLC6A4, HTR1A, HTR2A | rs6295, rs6311, rs6313 | [54,55,56] |
Fearfulness | SLC6A4, COMT, MAOA | rs4680, rs6323, rs6354 | [57,58,59] |
Impulsivity | DRD4, SLC6A4, COMT, HTR2A | rs1800955, rs25531, rs4680 | [40,41,60] |
Lack of Sleep | ABCC9, PER2, PER3, CRY1 | rs11046209, rs934945, rs228697 | [61,62,63] |
Depression | SLC6A4, BDNF, HTR2A | rs25531, rs6265, rs6313 | [42,64,65] |
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Rancelis, T.; Domarkiene, I.; Ambrozaityte, L.; Utkus, A. Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics. Genes 2023, 14, 1630. https://doi.org/10.3390/genes14081630
Rancelis T, Domarkiene I, Ambrozaityte L, Utkus A. Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics. Genes. 2023; 14(8):1630. https://doi.org/10.3390/genes14081630
Chicago/Turabian StyleRancelis, Tautvydas, Ingrida Domarkiene, Laima Ambrozaityte, and Algirdas Utkus. 2023. "Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics" Genes 14, no. 8: 1630. https://doi.org/10.3390/genes14081630