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Volume 14
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Review

Genomics of Treatable Traits in Asthma

by
Antonio Espuela-Ortiz
1,
Elena Martin-Gonzalez
1,
Paloma Poza-Guedes
2,3,
Ruperto González-Pérez
2,3 and
Esther Herrera-Luis
4,*
1
Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), 38200 San Cristóbal de La Laguna, Tenerife, Spain
2
Allergy Department, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Tenerife, Spain
3
Severe Asthma Unit, Hospital Universitario de Canarias, 38320 San Cristóbal de La Laguna, Tenerife, Spain
4
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
*
Author to whom correspondence should be addressed.
Genes 2023, 14(9), 1824; https://doi.org/10.3390/genes14091824
Submission received: 28 August 2023 / Revised: 12 September 2023 / Accepted: 16 September 2023 / Published: 20 September 2023
(This article belongs to the Special Issue Genetics of Complex Human Disease 2024)
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Abstract

The astounding number of genetic variants revealed in the 15 years of genome-wide association studies of asthma has not kept pace with the goals of translational genomics. Moving asthma diagnosis from a nonspecific umbrella term to specific phenotypes/endotypes and related traits may provide insights into features that may be prevented or alleviated by therapeutical intervention. This review provides an overview of the different asthma endotypes and phenotypes and the genomic findings from asthma studies using patient stratification strategies and asthma-related traits. Asthma genomic research for treatable traits has uncovered novel and previously reported asthma loci, primarily through studies in Europeans. Novel genomic findings for asthma phenotypes and related traits may arise from multi-trait and specific phenotyping strategies in diverse populations.
Keywords: asthma; GWAS; genomics; precision medicine; asthma phenotype; endotype asthma; GWAS; genomics; precision medicine; asthma phenotype; endotype

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MDPI and ACS Style

Espuela-Ortiz, A.; Martin-Gonzalez, E.; Poza-Guedes, P.; González-Pérez, R.; Herrera-Luis, E. Genomics of Treatable Traits in Asthma. Genes 2023, 14, 1824. https://doi.org/10.3390/genes14091824

AMA Style

Espuela-Ortiz A, Martin-Gonzalez E, Poza-Guedes P, González-Pérez R, Herrera-Luis E. Genomics of Treatable Traits in Asthma. Genes. 2023; 14(9):1824. https://doi.org/10.3390/genes14091824

Chicago/Turabian Style

Espuela-Ortiz, Antonio, Elena Martin-Gonzalez, Paloma Poza-Guedes, Ruperto González-Pérez, and Esther Herrera-Luis. 2023. "Genomics of Treatable Traits in Asthma" Genes 14, no. 9: 1824. https://doi.org/10.3390/genes14091824

APA Style

Espuela-Ortiz, A., Martin-Gonzalez, E., Poza-Guedes, P., González-Pérez, R., & Herrera-Luis, E. (2023). Genomics of Treatable Traits in Asthma. Genes, 14(9), 1824. https://doi.org/10.3390/genes14091824

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