Next Article in Journal
Developing a Machine-Learning ‘Smart’ PCR Thermocycler, Part 1: Construction of a Theoretical Framework
Previous Article in Journal
Arrest and Attack: Microtubule-Targeting Agents and Oncolytic Viruses Employ Complementary Mechanisms to Enhance Anti-Tumor Therapy Efficacy
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

A Proposal for the RNAome at the Dawn of the Last Universal Common Ancestor

by
Miryam Palacios-Pérez
1,2,* and
Marco V. José
1,*
1
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
2
Network of Researchers on the Chemical Emergence of Life (NoRCEL), Leeds LS7 3RB, UK
*
Authors to whom correspondence should be addressed.
Genes 2024, 15(9), 1195; https://doi.org/10.3390/genes15091195
Submission received: 10 August 2024 / Revised: 2 September 2024 / Accepted: 5 September 2024 / Published: 11 September 2024
(This article belongs to the Special Issue Tools for Evolutionary Genetics)

Abstract

From the most ancient RNAs, which followed an RNY pattern and folded into small hairpins, modern RNA molecules evolved by two different pathways, dubbed Extended Genetic Code 1 and 2, finally conforming to the current standard genetic code. Herein, we describe the evolutionary path of the RNAome based on these evolutionary routes. In general, all the RNA molecules analysed contain portions encoded by both genetic codes, but crucial features seem to be better recovered by Extended 2 triplets. In particular, the whole Peptidyl Transferase Centre, anti-Shine–Dalgarno motif, and a characteristic quadruplet of the RNA moiety of RNAse-P are clearly unveiled. Differences between bacteria and archaea are also detected; in most cases, the biological sequences are more stable than their controls. We then describe an evolutionary trajectory of the RNAome formation, based on two complementary evolutionary routes: one leading to the formation of essentials, while the other complemented the molecules, with the cooperative assembly of their constituents giving rise to modern RNAs.
Keywords: RNA; RNY code; primeval genetic code; extended genetic codes 1 and 2; evolution of genetic code; FUCA; LUCA RNA; RNY code; primeval genetic code; extended genetic codes 1 and 2; evolution of genetic code; FUCA; LUCA

Share and Cite

MDPI and ACS Style

Palacios-Pérez, M.; José, M.V. A Proposal for the RNAome at the Dawn of the Last Universal Common Ancestor. Genes 2024, 15, 1195. https://doi.org/10.3390/genes15091195

AMA Style

Palacios-Pérez M, José MV. A Proposal for the RNAome at the Dawn of the Last Universal Common Ancestor. Genes. 2024; 15(9):1195. https://doi.org/10.3390/genes15091195

Chicago/Turabian Style

Palacios-Pérez, Miryam, and Marco V. José. 2024. "A Proposal for the RNAome at the Dawn of the Last Universal Common Ancestor" Genes 15, no. 9: 1195. https://doi.org/10.3390/genes15091195

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop