New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture

Round 1

Reviewer 1 Report

I thought this was a well prepared document and I hope these thioamides can be exploited in the separation of metal-ions from ores. I am aware of the Zeneca Cu(II) extraction process where the ligands need long branched alkyl chains so they are water soluble and they extract the Cu(II) into an organic solvent. The thioamide group I think is stable enough and a good coordinator to soft metal ions, zinc. Good Luck

Author Response

Thank you very much for your kind comment.

Reviewer 2 Report

I suggest the publication of this manuscript after addressing some issues. Please see below:
I) Please present (figures) the NMR (1H and 13C), MS and IR spectra discussed in this manuscript. 
II) Please add the chromatograms (figures) obtained for purity analysis. 

These figures can be add in the Supplementary Material section. 

The presentation of these data in the form of figures will help the readers in future works.

Author Response

Thank you very much for your suggestion that would considerably contribute to the quality of the Manuscript. According to the suggestion, we added to Supplementary material scanned FTIR, NMR spectra, and some of GC-MS chromatograms as figures.

Reviewer 3 Report

This manuscript reports the optimization of the reaction conditions and efficiency for the large-scale synthesis of some thiocarbamates for the development of the flotation concentration technology. This reviewer is not familiar to this field but considers that the significance of this work in the field is adequately shown in the introduction part and overall research results are described properly.  One thing which should be pointed out is that most of numerical data given to Table S1 in the Supplementary Information should be like 6.30 (rather than 6,30). Also, the NMR spectra, FTIR spectra, and mass spectra should be provided in the Supplementary Information as much as possible rather than to provide the numerical data. Finally, English should be improved before publication

Author Response

We are thankful to Reviewer for the valuable observation and we corrected the Manuscript according to the suggestion:

1. All numerical data in Table S1 are corrected as Reviewer suggested.

2. We added to Supplementary material scanned FTIR and NMR spectra and some of GC-MS chromatograms as figures.

3. We carefully checked and corrected the English language throughout the Manuscript.