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Volume 11
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10.3390/jpm11040258
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Review

Diagnosis and Management of Glioblastoma: A Comprehensive Perspective

by
Vianney Gilard
1,2,*,
Abdellah Tebani
2,3,
Ivana Dabaj
3,4,
Annie Laquerrière
2,5,
Maxime Fontanilles
6,
Stéphane Derrey
1,
Stéphane Marret
3,4 and
Soumeya Bekri
2,3
1
Department of Neurosurgery, Rouen University Hospital, 76000 Rouen, France
2
Normandie Univ, UNIROUEN, CHU Rouen, INSERM U1245, 76000 Rouen, France
3
Department of Metabolic Biochemistry, Rouen University Hospital, 76000 Rouen, France
4
Department of Neonatology, Pediatric Intensive Care, and Pediatric Neurology, Rouen University Hospital, 76000 Rouen, France
5
Department of Pathology, Rouen University Hospital, 76000 Rouen, France
6
Department of Medical Oncology, Cancer Centre Henri Becquerel, 76038 Rouen, France
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2021, 11(4), 258; https://doi.org/10.3390/jpm11040258
Submission received: 9 March 2021 / Revised: 24 March 2021 / Accepted: 30 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Personalized Medicine in Brain Tumors)
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Abstract

Glioblastoma is the most common malignant brain tumor in adults. The current management relies on surgical resection and adjuvant radiotherapy and chemotherapy. Despite advances in our understanding of glioblastoma onset, we are still faced with an increased incidence, an altered quality of life and a poor prognosis, its relapse and a median overall survival of 15 months. For the past few years, the understanding of glioblastoma physiopathology has experienced an exponential acceleration and yielded significant insights and new treatments perspectives. In this review, through an original R-based literature analysis, we summarize the clinical presentation, current standards of care and outcomes in patients diagnosed with glioblastoma. We also present the recent advances and perspectives regarding pathophysiological bases as well as new therapeutic approaches such as cancer vaccination and personalized treatments.
Keywords: glioblastoma; molecular pathology; omics; pathogenesis; personalized therapies glioblastoma; molecular pathology; omics; pathogenesis; personalized therapies
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MDPI and ACS Style

Gilard, V.; Tebani, A.; Dabaj, I.; Laquerrière, A.; Fontanilles, M.; Derrey, S.; Marret, S.; Bekri, S. Diagnosis and Management of Glioblastoma: A Comprehensive Perspective. J. Pers. Med. 2021, 11, 258. https://doi.org/10.3390/jpm11040258

AMA Style

Gilard V, Tebani A, Dabaj I, Laquerrière A, Fontanilles M, Derrey S, Marret S, Bekri S. Diagnosis and Management of Glioblastoma: A Comprehensive Perspective. Journal of Personalized Medicine. 2021; 11(4):258. https://doi.org/10.3390/jpm11040258

Chicago/Turabian Style

Gilard, Vianney, Abdellah Tebani, Ivana Dabaj, Annie Laquerrière, Maxime Fontanilles, Stéphane Derrey, Stéphane Marret, and Soumeya Bekri. 2021. "Diagnosis and Management of Glioblastoma: A Comprehensive Perspective" Journal of Personalized Medicine 11, no. 4: 258. https://doi.org/10.3390/jpm11040258

APA Style

Gilard, V., Tebani, A., Dabaj, I., Laquerrière, A., Fontanilles, M., Derrey, S., Marret, S., & Bekri, S. (2021). Diagnosis and Management of Glioblastoma: A Comprehensive Perspective. Journal of Personalized Medicine, 11(4), 258. https://doi.org/10.3390/jpm11040258

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