Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse
Abstract
:1. Introduction
2. Pelvic Organ Prolapse
2.1. Aetiology
2.2. Anatomy, Pathophysiology, and Biomechanics
2.3. Treatment of POP
2.4. Clinical Adversities
3. Mesenchymal Stem/Progenitor Cells
4. Engineering Novel Meshes with eMSC
4.1. eMSC Non-Degradable Tissue Engineered Mesh
4.2. eMSC Degradable Tissue Engineered Mesh
4.3. Large Pre-Clinical Animal Models of POP
5. Potential Clinical Applications of eMSC
6. Limitations
7. Summary and Future Perspectives
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Source/Model | Cell Type/Scaffold | Properties | Reference |
---|---|---|---|
Human | Freshly isolated stromal cells |
| Chan et al., 2004 [52] |
Human | Freshly isolated CD146+PDGFRβ+(CD140b+CD146+) stromal cells |
| Schwab et al., 2007 [55] |
Human | SUSD2+ (W5C5+) eMSC |
| Masuda et al., 2012 [58] |
Human | SUSD2+ eMSC/Polyamide (PA) nanomesh cross-linked with gelatin (PAG) |
| Su et al., 2014 [67] |
Human/Rat (Subcutaneous wound) | SUSD2+ eMSC/Polyamide (PA) nanomesh cross-linked with gelatin (PAG) | Compared to mesh without eMSC:
| Ulrich et al., 2014 [11] Edwards et al., 2015 [68] |
Human | SUSD2+ eMSC |
| Gurung et al., 2015 [61] |
Sheep | CD271+CD45f− ovine eMSC |
| Letouzey et al., 2015 [69] |
Human/NSG and C57Bl6 mice (wound repair) | mCherry+ SUSD2+ eMSC/PAG mesh |
| Darzi et al., 2018 [70] |
Human/NSG mice | mCherry−labelledSUSD2+ eMSC |
| Gurung et al., 2018 [71] |
Human | A83-01 treated SUSD2+ eMSC |
| Gurung et al., 2018 [62] |
Sheep | Autologous ovine CD271+ eMSC/PAG mesh |
| Emmerson et al., 2019 [72] |
Human/NSG mice (wound repair) | SUSD2+ eMSC/PLCL nanomesh |
| Mukherjee et al., 2019 [73] Mukherjee et al., 2020 [66] |
Human/NSG mice (wound repair) | mCherry-labelled SUSD2+ eMSC/3D on 3D printed PCL nanomesh |
| Paul et al., 2019 [74] |
Human | A83-01 treated SUSD2+ eMSC |
| Lucciola et al., 2020 [63] |
Human | A83-01-treated SUSD2+ |
| Gurung et al., 2020 [75] |
Human/rat (vaginal birth injury) | SUSD2+ eMSC/AV+ALG hydrogel |
| Paul et al., 2021 [76] |
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Hennes, D.M.Z.B.; Rosamilia, A.; Werkmeister, J.A.; Gargett, C.E.; Mukherjee, S. Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse. J. Pers. Med. 2021, 11, 840. https://doi.org/10.3390/jpm11090840
Hennes DMZB, Rosamilia A, Werkmeister JA, Gargett CE, Mukherjee S. Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse. Journal of Personalized Medicine. 2021; 11(9):840. https://doi.org/10.3390/jpm11090840
Chicago/Turabian StyleHennes, David M. Z. B., Anna Rosamilia, Jerome A. Werkmeister, Caroline E. Gargett, and Shayanti Mukherjee. 2021. "Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse" Journal of Personalized Medicine 11, no. 9: 840. https://doi.org/10.3390/jpm11090840