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Volume 12
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10.3390/jpm12030327
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Review

Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

by
Igor Maiborodin
1,*,
Alfija Mansurova
1,
Alexander Chernyavskiy
1,
Alexander Romanov
1,
Vladimir Voitcitctkii
1,
Anna Kedrova
1,
Alexander Tarkhov
1,
Alena Chernyshova
2 and
Sergey Krasil’nikov
1
1
The E. Meshalkin National Medical Research Center, Ministry of Health of Russia, 30055 Novosibirsk, Russia
2
Tomsk National Research Medical Center, Cancer Research Institute, Russian Academy of Sciences, 634009 Tomsk, Russia
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(3), 327; https://doi.org/10.3390/jpm12030327
Submission received: 19 January 2022 / Revised: 18 February 2022 / Accepted: 18 February 2022 / Published: 22 February 2022
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Abstract

Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones.
Keywords: angiogenesis; vasculogenesis; vascularization; vessels; cancer; tumor angiogenesis; vasculogenesis; vascularization; vessels; cancer; tumor

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MDPI and ACS Style

Maiborodin, I.; Mansurova, A.; Chernyavskiy, A.; Romanov, A.; Voitcitctkii, V.; Kedrova, A.; Tarkhov, A.; Chernyshova, A.; Krasil’nikov, S. Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization. J. Pers. Med. 2022, 12, 327. https://doi.org/10.3390/jpm12030327

AMA Style

Maiborodin I, Mansurova A, Chernyavskiy A, Romanov A, Voitcitctkii V, Kedrova A, Tarkhov A, Chernyshova A, Krasil’nikov S. Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization. Journal of Personalized Medicine. 2022; 12(3):327. https://doi.org/10.3390/jpm12030327

Chicago/Turabian Style

Maiborodin, Igor, Alfija Mansurova, Alexander Chernyavskiy, Alexander Romanov, Vladimir Voitcitctkii, Anna Kedrova, Alexander Tarkhov, Alena Chernyshova, and Sergey Krasil’nikov. 2022. "Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization" Journal of Personalized Medicine 12, no. 3: 327. https://doi.org/10.3390/jpm12030327

APA Style

Maiborodin, I., Mansurova, A., Chernyavskiy, A., Romanov, A., Voitcitctkii, V., Kedrova, A., Tarkhov, A., Chernyshova, A., & Krasil’nikov, S. (2022). Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization. Journal of Personalized Medicine, 12(3), 327. https://doi.org/10.3390/jpm12030327

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