Efficacy of Endoscopic and Surgical Treatments for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Search Strategy
2.3. Inclusion and Exclusion Criteria
2.4. Study Selection
2.5. Data Extraction and Study Endpoint
2.6. Statistical Analysis
3. Results
3.1. Study Selection and Characteristics
3.2. Direct Meta-Analysis for the Efficacy of Endoscopic or Surgical Treatments
3.3. Network Meta-Analysis for the Efficacy of Endoscopic or Surgical Treatments
3.4. Sensitivity Analysis
3.5. Adverse Events
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A. Detailed Search Strategy
- MEDLINE (Search interface: PubMed)
- (reflux[tw] OR regurgitation[tw] OR GERD[tw] OR GORD[tw]) AND (radiofrequency[tw] OR stretta[tw] OR esophyX[tw] OR (transoral[tw] AND (plication[tw] OR fundoplication[tw])) OR (endoscopic plication[tw]) OR (endoscopic fundoplication[tw]) OR (endoscopic gastroplication[tw]) OR (endoscopic full-thickness plication[tw]) OR (endoscopic full-thickness fundoplication[tw]) OR plicator[tw] OR EndoCinch[tw] OR TIF[tw] OR (magnetic[tw] AND augmentation[tw]) OR MSA[tw] OR LINX[tw] OR (endoscopic polymer implantation[tw]) OR (nonresorbable copolymer implantation[tw]) OR (esophageal prosthesis[tw]) OR (oesophageal prosthesis[tw]) OR Enteryx[tw] OR Gatekeeper[tw] OR ((surgical[tw] OR laparoscopic[tw] OR Nissen[tw] OR Toupet[tw]) AND fundoplication[tw]) OR (total fundoplication[tw]) OR (partial fundoplication[tw]) OR (antireflux surgery[tw]) OR (anti-reflux surgery[tw])) AND random*[tw] AND (“1990/01/01”[Date - Publication] : “3000”[Date - Publication])
- EMBASE (Search interface: Ovid)
- 1: ((reflux or regurgitation or GERD or GORD) and (radiofrequency or stretta or esophyX or (transoral and (plication or fundoplication)) or endoscopic plication or endoscopic fundoplication or endoscopic gastroplication or endoscopic full-thickness plication or endoscopic full-thickness fundoplication or plicator or EndoCinch or TIF or (magnetic and augmentation) or MSA or LINX or endoscopic polymer implantation or nonresorbable copolymer implantation or esophageal prosthesis or oesophageal prosthesis or Enteryx or Gatekeeper or ((surgical or laparoscopic or Nissen or Toupet) and fundoplication) or total fundoplication or partial fundoplication or antireflux surgery or anti-reflux surgery) and random*).ab,ti.
- 2: Limit 1 to (english language and embase and yr=“1990 -Current”)
- Cochrane library
- #1: reflux or regurgitation or GERD or GORD
- #2: radiofrequency or stretta or esophyX
- #3: transoral and plication
- #4: transoral and fundoplication
- #5: #3 or #4
- #6: ‘endoscopic plication’ or ‘endoscopic fundoplication’ or ‘endoscopic gastroplication’ or ‘endoscopic full-thickness plication’ or ‘endoscopic full-thickness fundoplication’ or plicator or EndoCinch or TIF
- #7: magnetic and augmentation
- #8: MSA or LINX
- #9: ‘endoscopic polymer implantation’ or ‘nonresorbable copolymer implantation’ or ‘esophageal prosthesis’ or ‘oesophageal prosthesis’ or Enteryx or Gatekeeper
- #10: surgical or laparoscopic or Nissen or Toupet
- #11: fundoplication
- #12: #10 and #11
- #13: ‘total fundoplication’ or ‘partial fundoplication’ or ‘antireflux surgery’ or ‘anti-reflux surgery’
- #14: #2 or #5 or #6 or #7 or #8 or #9 or #12 or #13
- #15: random*
- #16: #1 and #14 and #15 (with Publication Year from 1990 to 2021, in Trials)
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Publication Year, First Author [Reference Number] | Country | Study Period | Study Population | Number of Participants | Arm 1 | Arm 2 | Age, Year | Male, % |
---|---|---|---|---|---|---|---|---|
2003, Corley [27] | USA | 2000–2001 | PPI-dependent patients with GERD | 64 | Radiofrequency energy delivery | Sham + PPI | Arm 1: mean 45 (SD 12) Arm 2: mean 52 (SD 15) | 51.6 |
2008, Coron [28] | France | 2003–2006 | PPI-dependent patients with GERD | 43 | Radiofrequency energy delivery | PPI | Arm 1: mean 50 (SD 10) Arm 2: mean 47 (SD 14) | 69.8 |
2010, Aziz [29] | USA | 2005–2006 | PPI-dependent patients with GERD | 24 | Radiofrequency energy delivery | Sham + PPI | Arm 1: mean 36.7 (SD 9.5) Arm 2: mean 32.0 (SD 8.3) | 66.7 |
2012, Arts [30] | Belgium | N/A | Patients with GERD | 22 | Radiofrequency energy delivery | Sham + PPI | Mean 46.5 (SD 2.4) | 22.7 |
2017, Kalapala [31] | India | 2015–2016 | Patients with refractory GERD | 20 | Radiofrequency energy delivery | Sham + PPI | Mean 36.5 (SD 13.0) | 100.0 |
2006, Montgomery [32] | Sweden | N/A | PPI-dependent patients with GERD | 46 | Endoscopic plication | Sham + PPI | Arm 1: median 42 (range 22–66) Arm 2: median 41 (range 19–66) | 32.6 |
2006, Rothstein [33] | USA and Europe | 2005 | PPI-dependent patients with GERD | 144 | Endoscopic plication | Sham + PPI | Arm 1: mean 48.1 (SD 13.1) Arm 2: mean 46.3 (SD 13.8) | 52.1 |
2007, Schwartz [34] | The Netherlands | 2003–2005 | PPI-dependent patients with GERD | 60 | Endoscopic plication | Sham + PPI | Arm 1: mean 45 (SD 12) Arm 2: mean 47 (SD 12) | 62.5 |
2015, Håkansson [35] | Sweden | 2011–2013 | PPI-dependent patients with GERD | 44 | Endoscopic plication | Sham + PPI | Arm 1: median 41 (range 21–67) Arm 2: median 62 (range 31–76) | 54.5 |
2015, Hunter [36] | USA | 2011–2013 | Patients with refractory GERD | 129 | Endoscopic plication | Sham + PPI | Arm 1: median 52 (range 22–74) Arm 2: median 55 (range 22–73) | 48.8 |
2015, Rinsma [37] | The Netherlands | 2008–2012 | PPI-dependent patients with GERD | 47 | Endoscopic plication | PPI | Mean 45 (range 19–68) | 63.8 |
2015, Trad [38] | USA | 2012 | Patients with refractory GERD | 60 | Endoscopic plication | PPI | Arm 1: median 54.8 (range 35.7–73.3) Arm 2: median 50.1 (range 32.5–63.3) | 45.0 |
2015, Witteman [39] | The Netherlands and USA | 2008–2011 | PPI-dependent patients with GERD | 60 | Endoscopic plication | PPI | Mean 44.7 (SD 12.9) | 63.3 |
2021, Kalapala [40] | India | 2017–2019 | PPI-dependent patients with GERD | 70 | Endoscopic plication | Sham + PPI | Median 36 (IQR 29–42) | 71.4 |
2005, Devière [41] | Germany, Beligum, and Italy | 2001–2004 | PPI-dependent patients with GERD | 64 | Reinforcement of the LES | Sham + PPI | Arm 1: mean 49.7 (SD 14.2) Arm 2: mean 48.6 (SD 10.2) | 67.2 |
2010, Fockens [42] | USA and the Netherlands | 2003–2005 | PPI-dependent patients with GERD | 118 | Reinforcement of the LES | Sham + PPI | Arm 1: mean 47.9 (SD 11.6) Arm 2: mean 52.6 (SD 11.8) | 63.6 |
2019, Bell [43] | USA | 2015–2017 | Patients with refractory GERD | 152 | Reinforcement of the LES | PPI | Median 46 (range 21–76) | 56.6 |
2000, Lundell [44] | Europe | 1991–1999 | Patients with GERD | 298 | Surgical fundoplication | PPI | N/A | 75.5 |
2005, Mahon [45] | UK | 1997–2001 | PPI-dependent patients with GERD | 217 | Surgical fundoplication | PPI | Arm 1: median 48 (IQR 39–56) Arm 2: median 47 (IQR 35–57) | 69 |
2006, Anvari [46] | Canada | 2000–2004 | PPI-dependent patients with GERD | 104 | Surgical fundoplication | PPI | Arm 1: mean 42.9 Arm 2: mean 42.1 | 52.9 |
2013, Grant [47] | UK | 2001–2004 | PPI-dependent patients with GERD | 357 | Surgical fundoplication | PPI | Arm 1: mean 46.7 (SD 10.3) Arm 2: mean 45.9 (SD 11.9) | 66.1 |
2016, Hatlebakk [48] | Europe | 2001–2009 | Patients with GERD | 554 | Surgical fundoplication | PPI | Mean 45.1 (SD 11.2) | 71.8 |
2006, Domagk [49] | Germany | 2002–2005 | PPI-dependent patients with GERD | 49 | Endoscopic plication | Reinforcement of the LES | Mean 48 (SD 15) | 53.1 |
2011, Svoboda [50] | Czech | 2007–2009 | Patients with GERD | 52 | Endoscopic plication | Surgical fundoplication | Arm 1: median 49 (range 25–69) Arm 2: median 55 (range 39–70) | 48.1 |
2012, Antoniou [51] | Austria | 2006–2010 | Patients with GERD | 56 | Endoscopic plication | Surgical fundoplication | Arm 1: mean 46.5 Arm 2: mean 46.3 | N/A |
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Gong, E.J.; Park, C.H.; Jung, D.H.; Kang, S.H.; Lee, J.Y.; Lim, H.; Kim, D.H.; Endoscopic Therapy and Instrument Research Group under the Korean Society of Neurogastroenterology and Motility. Efficacy of Endoscopic and Surgical Treatments for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis. J. Pers. Med. 2022, 12, 621. https://doi.org/10.3390/jpm12040621
Gong EJ, Park CH, Jung DH, Kang SH, Lee JY, Lim H, Kim DH, Endoscopic Therapy and Instrument Research Group under the Korean Society of Neurogastroenterology and Motility. Efficacy of Endoscopic and Surgical Treatments for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis. Journal of Personalized Medicine. 2022; 12(4):621. https://doi.org/10.3390/jpm12040621
Chicago/Turabian StyleGong, Eun Jeong, Chan Hyuk Park, Da Hyun Jung, Sun Hyung Kang, Ju Yup Lee, Hyun Lim, Do Hoon Kim, and Endoscopic Therapy and Instrument Research Group under the Korean Society of Neurogastroenterology and Motility. 2022. "Efficacy of Endoscopic and Surgical Treatments for Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-Analysis" Journal of Personalized Medicine 12, no. 4: 621. https://doi.org/10.3390/jpm12040621