ORIFICE (Interventional Radiotherapy for Face Aesthetic Preservation) Study: Results of Interdisciplinary Assessment of Interstitial Interventional Radiotherapy (Brachytherapy) for Periorificial Face Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Factors | n (%) |
---|---|
Sex | |
Male | 24 (60%) |
Female | 16 (40%) |
Age (mean) | 66.5 years (range 39–94) |
Primary site | |
Nasal vestibule | 26 (65%) |
Lip | 10 (25%) |
Eyelid | 4 (10%) |
T stage | |
Nasal vestibule * | T1 10 (38%)/T2 15 (58%)/T3 1(4%) |
Lip ** | T1 7 (70%)/T2 3 (30%) |
Eyelid ** | T1 4 (100%) |
Initial N | |
N− | 38 (95%) |
N+ | 2 (5%) |
Histology | |
SCC | 30 (75%) |
BCC | 10 (25%) |
Follow-up (mean) | 24 months (range 6–40) |
Step 1: Pre-planning |
a. CT or MRI to define the ideal position and insertion of the catheters |
b. CT-based pre-planning |
c. Catheter insertion calculation with reference to bony landmarks |
Step 2: Implant technique |
a. Bimanual catheter implantation carried out under local or general anaesthesia |
b. Catheter insertion carefully avoiding injury |
c. Catheters sewn to the skin for stability |
Step 3: Treatment planning and delivery |
a. CT definition of the actual catheter position for 3D treatment planning |
b. CT-based IRT planning and optimization |
c. Treatment delivery |
Primary Site | Dose | Fractionation |
---|---|---|
Nose vestibule | 44 Gy | 3 Gy b.i.d. (first and last fraction 4 Gy) |
Lip | 45 Gy | 5 Gy b.i.d. |
Eyelid | 49 Gy | 3.5 Gy b.i.d. |
Category | Definition |
---|---|
T1 | Limited to the nasal vestibule, relatively superficial and involving 1 or more sites within the nasal vestibule |
T2 | Extended from the nasal vestibule to the adjacent structures, such as the upper nasal septum, upper lip, philtrum, skin of the nose and/or nasolabial fold, but they are not fixed to the underlying bone |
T3 | Massive, with extension to the hard palate, bucco-gingival sulcus, large portion of the upper lip, upper septum, turbinate and/or paranasal sinus, fixed with deep muscle or bone involvement |
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Tagliaferri, L.; Giarrizzo, I.; Fionda, B.; Rigante, M.; Pagliara, M.M.; Casà, C.; Parrilla, C.; Lancellotta, V.; Placidi, E.; Salvati, A.; et al. ORIFICE (Interventional Radiotherapy for Face Aesthetic Preservation) Study: Results of Interdisciplinary Assessment of Interstitial Interventional Radiotherapy (Brachytherapy) for Periorificial Face Cancer. J. Pers. Med. 2022, 12, 1038. https://doi.org/10.3390/jpm12071038
Tagliaferri L, Giarrizzo I, Fionda B, Rigante M, Pagliara MM, Casà C, Parrilla C, Lancellotta V, Placidi E, Salvati A, et al. ORIFICE (Interventional Radiotherapy for Face Aesthetic Preservation) Study: Results of Interdisciplinary Assessment of Interstitial Interventional Radiotherapy (Brachytherapy) for Periorificial Face Cancer. Journal of Personalized Medicine. 2022; 12(7):1038. https://doi.org/10.3390/jpm12071038
Chicago/Turabian StyleTagliaferri, Luca, Ilaria Giarrizzo, Bruno Fionda, Mario Rigante, Monica Maria Pagliara, Calogero Casà, Claudio Parrilla, Valentina Lancellotta, Elisa Placidi, Alessandra Salvati, and et al. 2022. "ORIFICE (Interventional Radiotherapy for Face Aesthetic Preservation) Study: Results of Interdisciplinary Assessment of Interstitial Interventional Radiotherapy (Brachytherapy) for Periorificial Face Cancer" Journal of Personalized Medicine 12, no. 7: 1038. https://doi.org/10.3390/jpm12071038