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Volume 12
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Article

Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans

by
Dae-Jeong Koo
1,
Mi Yeon Lee
2,
Inha Jung
3,
Sun Joon Moon
4,
Hyemi Kwon
4,
Eun-Jung Rhee
4,
Cheol-Young Park
4,
Won-Young Lee
4,
Ki Won Oh
4 and
Se Eun Park
4,*
1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Changwon Fatima Hospital, 45, Changi-daero, Uichang-gu, Changwon-si 51394, Korea
2
Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29, Saemunan-ro, Jongno-gu, Seoul 03181, Korea
3
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Korea
4
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29, Saemunan-ro, Jongno-gu, Seoul 03181, Korea
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(7), 1142; https://doi.org/10.3390/jpm12071142
Submission received: 22 June 2022 / Revised: 10 July 2022 / Accepted: 13 July 2022 / Published: 14 July 2022
(This article belongs to the Section Clinical Medicine, Cell, and Organism Physiology)
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Abstract

This study evaluated whether glomerular hyperfiltration (GHF) could predict nonalcoholic fatty liver disease (NAFLD) and fibrosis. A longitudinal cohort study including 147,479 participants aged 20–65 years without NAFLD and kidney disease at baseline was performed. GHF cutoff values were defined as age- and sex-specific estimated glomerular filtration rate (eGFRs) above the 95th percentile, and eGFR values between the 50th and 65th percentiles were used as reference groups. NAFLD was diagnosed via abdominal ultrasonography, and the fibrosis status was evaluated using the NAFLD fibrosis score and Fibrosis-4. During 598,745 person years of follow-up (median, 4.6 years), subjects with GHF at baseline had the highest hazard ratio (HR) for the development of NAFLD (HR 1.21; 95% CI 1.14–1.29) and fibrosis progression (HR 1.42; 95% CI 1.11–1.82) after adjusting for confounding factors. A higher baseline eGFR percentile maintained a higher risk of NAFLD and fibrosis probability. The persistent GHF group during follow-up had the highest HR for NAFLD compared to the persistent non-GHF group (HR 1.31; 95% CI 1.14–1.51). These results were consistent in all subgroups and statistically more prominent in participants without diabetes. GHF was positively associated with increased risk of NAFLD and probability of liver fibrosis in healthy adults.
Keywords: nonalcoholic fatty liver disease; liver fibrosis; glomerular filtration rate; obesity; insulin resistance; cohort study nonalcoholic fatty liver disease; liver fibrosis; glomerular filtration rate; obesity; insulin resistance; cohort study
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MDPI and ACS Style

Koo, D.-J.; Lee, M.Y.; Jung, I.; Moon, S.J.; Kwon, H.; Rhee, E.-J.; Park, C.-Y.; Lee, W.-Y.; Oh, K.W.; Park, S.E. Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans. J. Pers. Med. 2022, 12, 1142. https://doi.org/10.3390/jpm12071142

AMA Style

Koo D-J, Lee MY, Jung I, Moon SJ, Kwon H, Rhee E-J, Park C-Y, Lee W-Y, Oh KW, Park SE. Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans. Journal of Personalized Medicine. 2022; 12(7):1142. https://doi.org/10.3390/jpm12071142

Chicago/Turabian Style

Koo, Dae-Jeong, Mi Yeon Lee, Inha Jung, Sun Joon Moon, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Won-Young Lee, Ki Won Oh, and Se Eun Park. 2022. "Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans" Journal of Personalized Medicine 12, no. 7: 1142. https://doi.org/10.3390/jpm12071142

APA Style

Koo, D.-J., Lee, M. Y., Jung, I., Moon, S. J., Kwon, H., Rhee, E.-J., Park, C.-Y., Lee, W.-Y., Oh, K. W., & Park, S. E. (2022). Increased Risk of NAFLD in Adults with Glomerular Hyperfiltration: An 8-Year Cohort Study Based on 147,162 Koreans. Journal of Personalized Medicine, 12(7), 1142. https://doi.org/10.3390/jpm12071142

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