Long-Term Use of Silybum marianum fruit extract Contributes to Homeostasis in Acne-Prone Skin—A 12-Month Follow-Up International “Real Life” Cohort Study

Round 1

Reviewer 1 Report

Dear Prof. Dr. Chief in Editors, editors, and authors

Happy day.

The paper need some improvement concerning the following points.

1-      The quality of all images need to be improved.

2-      Some references style is in correct.

3-      Kindly remove the abbreviations from the title and the abstract.

4-      Kindly format Silybum Marianum to be italic Silybum Marianum in the title. And in the rest of the text as S. Marianum.

With my pleasure

Amro Amara

Comments for author File: Comments.pdf

Author Response

Dear reviewer, 

thanks for your comments to improve our manuscript. Please find enclose the confirmation of modifications and the new version of manuscript.

1- The quality of all images need to be improved we have sent to Agnes Cao contact editor the JPEG format for all figures.

2-      Some references style is in correct : all the references were modified  in the manuscript (we remplace author, year... by  number of reference in the bibliography, easier to read)

3-      Kindly remove the abbreviations from the title and the abstract : it was done

4-      Kindly format Silybum Marianum to be italic Silybum Marianum in the title. And in the rest of the text as S. Marianum: it was done.
Kind regards.

NOCERA Therese

Reviewer 2 Report

The manuscript might be interesting. However, it is extremely hard to read, it seems that the submitted version is not the final one, lacking editing and organization.

I suggest major revision as follows:

Abstract: Methods: Add the treatments, number of volunteers belongs to the methods, not results." The following sentence very hard to read and seems like information about the treatment is missing. : "There was sustained, highly significant decrease over months of lesion counts 24 and other efficacy markers, associated with significant decrease of global micro-comedones quantity on CSSS."

Introduction: Long sentences, and it is hard to understand the aim of each sentence. Need extensive English editing

May be if the Authors start with defining the "micro-comedones", then the first paragraph will be clearer.

Typo: Line 56 "In a proof-of-concept study in 23 subjects" should read on 23 subject

Line 72, 72 seems to be a copy-paste that is not revised to suit the context.

The methods are not clear

The study design is appropriate, and the findings are interesting

More than one font is used throughout the manuscript. Please be consistent.

I think the final editing and revising step is missing, again making the manuscript very difficult to read and understand

Line 131, the paragraph cannot be started with "54"

Figures. All of them need to be revised, renumbered. A total mess!!!! The captions are written twice before and after the figure. Figure 2 Figure 3 the Figure 2????  

References are relevant but need to be organized properly   

 

Author Response

Dear reviewer, 

thanks for your comments to improve our manuscript. Please find enclose the confirmation of modifications and the new version of manuscript. Please find our revision in the file enclose

Abstract: Methods: Add the treatments, number of volunteers belongs to the methods, not results." The following sentence very hard to read and seems like information about the treatment is missing. : "There was sustained, highly significant decrease over months of lesion counts 24 and other efficacy markers, associated with significant decrease of global micro-comedones quantity on CSSS." : we do our best to improve the abstract following your recommendations 

Introduction: Long sentences, and it is hard to understand the aim of each sentence. Need extensive English editing Revision 

May be if the Authors start with defining the "micro-comedones", then the first paragraph will be clearer : we defined the microcomedones Lines 45 to 54

Typo: Line 56 "In a proof-of-concept study in 23 subjects" should read on 23 subject: ok for modification 

Line 72, 72 seems to be a copy-paste that is not revised to suit the context.: we modified as asked

The methods are not clear : we improuved

The study design is appropriate, and the findings are interesting: thank you for positive comments

More than one font is used throughout the manuscript. Please be consistent. : we modified in coherance all the manuscript 

I think the final editing and revising step is missing, again making the manuscript very difficult to read and understand : We apologize for that 

Line 131, the paragraph cannot be started with "54": ok modified

Figures : all the figures were revised (suppression of caption on the top)