Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology
Abstract
:1. Introduction
2. Materials and Methods
2.1. Molecular Tumor Board
2.2. Patient Population
2.3. Sequencing Assays
2.4. Conventional ERBB2 Evaluation
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Detection and Management of CRC Patients with ERBB2 Amplification or Mutation
3.3. Exemplatory Case Reviews of Patients with ERBB2 Amplification in mCRC
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | Number of Patients | |
---|---|---|
Sex | ||
Male | 65 (60.7%) | |
Female | 42 (39.3%) | |
Primary tumor localization | ||
Caecum/appendix | 10 (9.3%) | |
Ascending colon | 8 (7.5%) | |
Transverse colon | 5 (4.7%) | |
Descending colon | 3 (2.8%) | |
Sigmoid colon | 21 (19.6%) | |
Rectum | 59 (55.1%) | |
More than one primary tumor location | 1 (0.9%) | |
UICC stage at diagnosis | ||
I | 1 (0.9%) | |
II | 9 (8.4%) | |
III | 28 (26.2%) | |
IV | 65 (60.7%) | |
Unknown | 4 (3.7%) | |
Age at diagnosis in years | ||
Median | 54.3 | |
Range | 23.4 to 83.1 | |
Age at presentation in MTB in years | ||
Median | 57.3 | |
Range | 23.8 to 83.3 | |
Number of MTB presentations with individual GCP | ||
One | 83 (77.6%) | |
Two | 24 (22.4%) | |
ERBB2 scope of most comprehensive panel used for GCP | ||
No analysis of ERBB2 | 7 (7.5%) | |
Detection of ERBB2 mutations | 56 (52.3%) | |
Detection of ERBB2 mutations & alterations | 44 (41.1%) | |
Status at last follow up | ||
Deceased | 64 (59.8%) | |
Alive | 43 (40.2%) |
Characteristic | Number of Patients | |
---|---|---|
Sex | ||
Male | 2 (50%) | |
Female | 2 (50%) | |
Primary tumor localisation | ||
Sigmoid colon | 1 (25%) | |
Rectum | 3(75%) | |
Age at diagnosis in years | ||
Median | 62 | |
Range | 25–66 | |
Received ERBB2 specific treatment | ||
Yes | 2 (50%) | |
No | 2 (50%) | |
Status at last follow up | ||
Deceased | 2 (50%) | |
Alive | 2 (50%) |
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Buchholz, S.M.; Nause, N.; König, U.; Reinecke, J.; Steuber, B.; Ammer-Herrmenau, C.; Reuter-Jessen, K.; Bohnenberger, H.; Biggemann, L.; Braulke, F.; et al. Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology. J. Pers. Med. 2023, 13, 1701. https://doi.org/10.3390/jpm13121701
Buchholz SM, Nause N, König U, Reinecke J, Steuber B, Ammer-Herrmenau C, Reuter-Jessen K, Bohnenberger H, Biggemann L, Braulke F, et al. Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology. Journal of Personalized Medicine. 2023; 13(12):1701. https://doi.org/10.3390/jpm13121701
Chicago/Turabian StyleBuchholz, Soeren M., Nelia Nause, Ute König, Johanna Reinecke, Benjamin Steuber, Christoph Ammer-Herrmenau, Kirsten Reuter-Jessen, Hanibal Bohnenberger, Lorenz Biggemann, Friederike Braulke, and et al. 2023. "Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology" Journal of Personalized Medicine 13, no. 12: 1701. https://doi.org/10.3390/jpm13121701
APA StyleBuchholz, S. M., Nause, N., König, U., Reinecke, J., Steuber, B., Ammer-Herrmenau, C., Reuter-Jessen, K., Bohnenberger, H., Biggemann, L., Braulke, F., Neesse, A., Ellenrieder, V., Ströbel, P., Adler, M., & König, A. (2023). Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology. Journal of Personalized Medicine, 13(12), 1701. https://doi.org/10.3390/jpm13121701