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Article

Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality

by
Julian Lommen
1,
Lara Schorn
1,*,
Christoph Sproll
1,
Valentin Kerkfeld
1,
Adem Aksu
2,
Frank Reinauer
2,
Norbert R. Kübler
1,
Wilfried Budach
3,
Majeed Rana
1 and
Bálint Tamaskovics
3
1
Department of Oral, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany
2
Karl Leibinger Medizintechnik GmbH & Co. KG, Kolbinger Str. 10, 78570 Mühlheim, Germany
3
Department of Radiation Oncology, University Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2023, 13(2), 236; https://doi.org/10.3390/jpm13020236
Submission received: 11 January 2023 / Revised: 22 January 2023 / Accepted: 27 January 2023 / Published: 28 January 2023
(This article belongs to the Special Issue Personalized Medicine in Head and Neck Cancer)
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Abstract

:
Midfacial reconstruction after tumor resection surgery is commonly conducted by using autologous bone grafts or alloplastic implants. Titanium is the most frequently used osteosynthesis material in these cases but causes disturbing metallic artifacts in CT imaging. The purpose of this experimental study was to evaluate whether the use of midfacial polymer implants reduces metallic artifacts in CT imaging to improve image quality. Zygomatic titanium (n = 1) and polymer (n = 12) implants were successively implanted in a human skull specimen. Implants were analyzed for their effect on Hounsfield Unit values (streak artifacts) and virtual growth in CT images (blooming artifacts) as well as image quality. Multi-factorial ANOVA and Bonferroni’s post hoc test were used. Titanium (173.7 HU; SD ± 5.1) and hydroxyapatite containing polymers (155.3 HU; SD ± 5.9) were associated with significantly more streak artifacts compared to all other polymer materials. There was no significant difference in blooming artifacts between materials. The metallic artifact reduction algorithm showed no significant difference. Image quality was slightly better for polymer implants compared to titanium. Personalized polymer implants for midfacial reconstruction significantly reduce metallic artifacts in CT imaging which improves image quality. Hence, postoperative radiation therapy planning and radiological tumor aftercare around the implants are facilitated.

1. Introduction

Facial reconstruction after tumor resection surgery of oral squamous cell carcinoma (OSCC) is a challenging procedure that aims at restoring oral function and esthetics to lower patient morbidity [1]. In the majority of surgical OSCC therapies, tumor resection includes parts of the maxillary or mandibular bone which often needs to be reconstructed by means of stable osteosynthesis with or without a bone graft [2]. To speed up rehabilitation, tumor resection and concomitant reconstruction are routinely conducted simultaneously in one operation, especially in cases where adjuvant radiation therapy is required [3]. This ensures the postoperative start of radiation therapy as soon as possible to maximize the therapeutic effect. Contemporary osteosynthesis materials for the mandible and midface are made of titanium which provides excellent biocompatibility and mechanical stability to withstand bite forces. It is generally agreed upon that navigation-assisted surgery and patient-specific osteosynthesis are the gold standard for complex reconstructive procedures to provide superior fitting accuracy compared to manually bending plates [4,5]. However, titanium is well known for causing substantial metallic artifacts in computer tomography (CT) imaging [6,7,8,9]. These artifacts negatively affect assessment of Hounsfield Units (HU) which are a radiological measure of tissue density [10]. For radiologists and radio-oncologists this impedes radiological follow-up care as well as radiation therapy planning, since calculation of dose distribution is highly dependent on tissue density assessed based on HU values [11,12,13]. Software algorithms to reduce metal artifacts (MAR) have not been sufficient to fully counteract this effect [14]. Recently, radiolucent polymer mandible reconstruction plates consisting of polyetheretherketone (PEEK), polyetherketoneketone (PEKK), polyphenylsulfone (PPSU) and polyethylene (PE) were found to significantly reduce streak and blooming artifacts in CT images compared to titanium [15]. In an ensuing investigation, it was shown that PEEK, fiber enforced PEEK (f-PEEK) and PEKK provide sufficient fatigue strength to withstand chewing cycles over the cause of at least one year after segmental mandibulectomy [16]. While these are promising results for mandible reconstruction, there are almost no studies analyzing the radiological effects of polymer plates for midfacial reconstruction. The polyaromatic thermoplastic PEEK is ubiquitously used in cranioplasty and craniofacial reconstructive surgery as a light-weight alloplastic onlay graft [17]. PEEK shows good mechanical properties and biocompatibility [18]. Besides its advantageous effect on CT image quality, carbon fiber-reinforced PEEK was shown to reduce dose perturbation in radiation therapy of spinal tumors to less than 5%, compared to more than 30% dose perturbation for titanium [19]. Silicon nitride ceramic-based miniplates for midfacial reconstruction have been shown to cause no artifacts in CT and magnetic resonance (MR) imaging [20]. However, another study found zirconium oxide ceramics to produce strong artifacts in CT images [15]. Therefore, the radiolucent properties of polymers might be more beneficial compared to ceramics. Many different polymer compositions of PEEK, PEKK and PPSU exist for potential medical application. PEEK and PEKK provide fatigue resistance, high yield strength, durability and are lightweight [21]. However, there are no relevant scientific data on many new polymers for patient-specific osteosynthesis in oncologic or traumatic midfacial reconstruction.
Therefore, this study analyzed 12 alloplastic onlay grafts consisting of different polymer compositions for midfacial reconstruction in comparison to a titanium mesh. The aim was to evaluate artifact occurrence and CT image quality compared to a conventional titanium mesh. Additionally, the effect of polymers on radiation dose calculation was analyzed.

2. Materials and Methods

2.1. Ethical Approval

The Ethics Commission of Heinrich Heine University Düsseldorf gave ethical approval for this experimental study and appointed the trial registration number 2020-993.

2.2. Human Cadaveric Specimen

A fresh-frozen (−18 °Celsius [°C]) edentulous human cadaveric skull was obtained from the Institute of Anatomy I of Heinrich Heine University Düsseldorf. Written informed consent for use of the body in experimental medical studies was obtained from the body donor as a standard practice. The skull had no dental or other cranial metallic implants to allow for sole artifact assessment of the inserted implants. For preoperative CT image acquisition and subsequent surgical implantation of titanium and polymer osteosynthesis materials, the human skull specimen was thawed.

2.3. Virtual Planning and Manufacturing of Patient-Specific Implants

Digital Imaging and Communications in Medicine (DICOM) dataset files of 1 mm, thin-sliced CT-scans of the skull were generated. These data were used for computer-aided design and manufacturing (CAD/CAM) of all polymer implants.
The uploading of DICOM data, virtual segmentation and 3D-reconstruction were conducted using the software Individual Patient Solution, IPS Gate® (KLS Martin Group®, Tuttlingen, Germany) (Figure 1A–C). The conversion of the 3D virtual model to stereolithography (STL) image files was carried out using Mimics 21.0© (Materialise NV, Leuven, Belgium). Webinar-based (Microsoft© Teams, Redmond, WA, USA) virtual surgery defined the region for the different zygomatic polymer implants on the left side of the skull (Figure 1D–F). The dimensions of all polymer implants were defined using Geomagic© Freeform Plus© (3D Systems©, Rock Hill, SC, USA). The titanium mesh was manually adapted to the zygomatic defect region intraoperatively. All polymer implants were manufactured using additive Fused Filament Fabrication (FFF).

2.4. Preparation

Preparation of the zygomatic bone was conducted via a maxillary vestibular approach on the left side only. A horizontal incision from the first incisor to the first molar 5 mm superior to the mucogingival junction was made using a No. 15 blade. Subperiosteal elevators were used to expose the zygomatic bone for an adequate overview. The Osteotomy of the left zygomatic bone was conducted with rotating burrs, without the use of resection guides. The infraorbital nerve was preserved. The defect was then bridged by the different implants as virtually planned preoperatively.

2.5. Plates and Screws

TM (KLS Martin Group®, Tuttlingen, Germany), VK iC4800 (EVONIK Industries AG, Essen, Germany), KU PEKK (KUMOVIS GmbH, Munich, Germany), VK i4 (EVONIK Industries AG, Essen, Germany), Radel PPSU (Solvay GmbH, Hannover, Germany), PEKK nature (PEKK Filament, KUMOVIS GmbH, Munich, Germany), TE PEEK (Ensinger GmbH, Nufringen, Germany), VK A1 (EVONIK Industries AG, Essen, Germany), VK A2 (EVONIK Industries AG, Essen, Germany), VK A3 (EVONIK Industries AG, Essen, Germany), VK B1 (EVONIK Industries AG, Essen, Germany), VK B2 (EVONIK Industries AG, Essen, Germany) and VK B3 (EVONIK Industries AG, Essen, Germany) implants were used in this trial (Figure 2). Table 1 provides a list of all implants. For fixation, all implants were fixated with one titanium MAXDrive® screw with a diameter of 1.5 × 8 mm (KLS Martin Group®, Tuttlingen, Germany). Screw holes were prepared with a 1.1 × 8 mm irrigated drill. The thickness of all polymer implants was 4.65 mm (Figure 3), and the titanium mesh was 0.45 mm thick.

2.6. Computer Tomography (CT) Image Acquisition

CT imaging (Brilliance CT Big Bore®, Philips Healthcare, Amsterdam, The Netherlands) of the skull was conducted pre- and postoperatively. Accurate skull positioning in CT was guaranteed by the use of a 1.6 mm thick immobilization mask (MR-03 softfix miniperforation, UNGER Medizintechnik, Mülheim-Kärlich, Germany). CT parameters were set to tube voltage (120 kV), axial scan mode (106 slices with 1 mm slice thickness), detector width (collimation) of 24 mm (16 × 1.5), image resolution 512 × 512 pixels and 0.5 s/circle rotation time. Image reconstruction used a 12-bit CHU scale. All images were reconstructed both with and without the MAR algorithm (Philips Healthcare, Amsterdam, The Netherlands). Since international guidelines only suggest clinical CT slice thicknesses of 2–3 mm, the 1 mm slice thickness of the presented study offers a more sophisticated analysis of CT artifacts [22,23].

2.7. Image Analysis

The software ImageJ (ImageJ 1.48, Wayne Rasband, National Institute of Health, Bethesda, MD, USA) was used for image analysis. As suggested by the software, additional plugins used were CT Window Level and SPICE-CT Package for Computed Tomography QC (Loveland, J.; 2011). All imported DICOM images were analyzed in axial orientation and a specific soft tissue HU window. Streak artifacts occur due to beam-hardening and photon starvation [24] and change HU values. Since beam-hardening artifacts are caused by metallic objects, such as titanium plates, the focus of this study was particularly laid upon streak and blooming artifacts. Patient-based or hardware-based artifacts were not assessed in the design of this study. For artifact assessment, three circular regions of interest (ROI) were selected per image and positioned over (1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland using the ROI manager (Figure 4). For evaluation of artifact occurrence, mean HU values were measured for all ROI. An image without implants served as a reference for soft tissue HU. Partial volume and beam hardening effects cause blooming artifacts, which are also dependent on the attenuation of the implant [15,25,26]. Tan et al. (2016) and Kasparek et al. (2019) suggested that the best option for the assessment of booming artifacts is the comparison of the actual implant size to the CT measured size [26,27]. This method has been validated in other studies [15]. The virtual growth of all implants in CT images was analyzed by three different radio-oncologists using PACS (IDS7, Sectra AB, Linköping, Sweden). Image quality was further assessed on a five-point Likert scale (1: very good; 2: good; 3: intermediate; 4: poor; 5: very poor).

2.8. Statistics

Statistical evaluation was conducted using IBM© SPSS© Statistics for Mac (Version 27; IBM, Armonk, NY, United States). Normality testing was performed using the Shapiro–Wilk test. Data are described as means and standard deviation (SD). Multi-factorial analysis of variance (ANOVA) followed by Bonferroni’s post hoc analysis was used for comparison between groups. A p value < 0.05 was considered statistically significant. The implant material was the primary predictor variable. An image without implant served as control. The prospective HU value was the outcome variable. The median of the Likert scale was used for the analysis of image quality and comparison between implants. The intraclass correlation coefficient (ICC) was used to calculate inter-rater and intra-rater agreement. ICC values were interpreted according to Cicchetti et al. (1994) and Koo et al. (2016) [15,28,29].

3. Results

3.1. Streak Artifacts

3.1.1. Implant Material

TM (173.7 HU; SD ± 5.1) caused significantly more streak artifacts (measured as mean HU value increase) in CT images compared to control (52.3 HU; SD ± 3.5; p < 0.001), KU PEKK (80.7 HU; SD ± 7.4; p < 0.001), VK i4 (74.7 HU; SD ± 5.5; p < 0.001), Radel PPSU (75.7 HU; SD ± 5.0; p < 0.001), PEKK nature (77.0 HU; SD ± 5.3; p < 0.001), TE PEEK (74.7 HU; SD ± 6.0; p < 0.001), VK A1 (63.3 HU; SD ± 5.9; p < 0.001), VK A2 (80.3 HU; SD ± 5.0; p < 0.001), VK A3 (68.0 HU; SD ± 7.5; p < 0.001), VK B1 (64.7 HU; SD ± 6.7; p < 0.001), VK B2 (62.3 HU; SD ± 7.6; p < 0.001) and VK B3 (66.0 HU; SD ± 9.5; p < 0.001). No statistical difference in streak artifacts between TM (173.7 HU; SD ± 5.1) and VK iC4800 (155.3 HU; SD ± 5.9; p < 0.134) was found. There were also no statistical differences between control (52.3 HU; SD ± 3.5) and KU PEKK (80.7 HU; SD ± 7.4; p < 0.084), VK i4 (74.7 HU; SD ± 5.5; p < 0.123), Radel PPSU (75.7 HU; SD ± 5.0; p < 0.125), PEKK nature (77.0 HU; SD ± 5.3; p < 0.110), TE PEEK (74.7 HU; SD ± 6.0; p < 0.125), VK A1 (63.3 HU; SD ± 5.9; p < 0.213), VK A2 (80.3 HU; SD ± 5.0; p < 0.085), VK A3 (68.0 HU; SD ± 7.5; p < 0.151), VK B1 (64.7 HU; SD ± 6.7; p < 0.164), VK B2 (62.3 HU; SD ± 7.6; p < 0.243) and VK B3 (66.0 HU; SD ± 9.5; p < 0.155).
Figure 5, Figure 6 and Figure 7 and Table 2 provide a graphical display of differences in streak artifacts for all implant materials.

3.1.2. Metallic Artifact Reduction Algorithm

CT sequences with and without activation of the metallic artifact reduction algorithm showed no significant differences in streak artifact formation for all implants (TM [p = 0.765]; VK iC4800 [p = 0.654], KU PEKK [p = 0.713]; VK i4 [p = 0.574]; Radel PPSU [p = 0.798]; PEKK nature [p = 0.591]; TE PEEK [p = 0.913]; VK A1 [p = 0.853]; VK A2 [p = 0.576]; VK A3 [p = 0.672]; VK B1 [p = 0.742]; VK B2 [p = 0.611] and VK B3 [p = 0.654]).

3.2. Blooming Artifacts

3.2.1. Implant Material

No significant blooming artifacts occurred for TM (p = 0.987), VK iC4800 (p = 0.956), KU PEKK (p = 0.956), VK i4 (p = 0.987), Radel PPSU (p = 0.987), PEKK nature (p = 0.932), TE PEEK (p = 0.987), VK A1 (p = 0.956), VK A2 (p = 0.987), VK A3 (p = 0.932), VK B1 (p = 0.956), VK B2 (p = 0.932) and VK B3 (p = 0.987). Mean values, standard deviation and virtual growth are displayed in Table 3.

3.2.2. Metallic Artifact Reduction Algorithm

CT sequences with and without activation of the metallic artifact reduction algorithm showed no significant differences in blooming artifact formation for all implants (TM [p = 0.654]; VK iC4800 [p = 0.923], KU PEKK [p = 0.764]; VK i4 [p = 0.649]; Radel PPSU [p = 0.945]; PEKK nature [p = 0.866]; TE PEEK [p = 0.791]; VK A1 [p = 0.548]; VK A2 [p = 0.689]; VK A3 [p = 0.779]; VK B1 [p = 0.914]; VK B2 [p = 0.659] and VK B3 [p = 0.760]).

3.3. Image Quality

Titanium as well as the polymer implants all showed very good and good image quality. Median image quality for TM, VK iC4800, KU PEKK, Radel PPSU, PEKK nature, VK A1, VK A2, VK A3 and VK B1 was assessed to be good. VK i4, TE PEEK, VK B2 and VK B3 showed very good image quality. Median values for image quality for each material are displayed in Table 3.

4. Discussion

Metallic artifacts in CT imaging still pose a major challenge for radiological diagnostics and radiation therapy planning in craniofacial surgery as they reduce CT image quality [30]. Accurate assessment of Hounsfield Units (HU) adjacent to metallic implants is impossible. Hence, the design and manufacture of radiolucent osteosynthesis materials for craniofacial reconstruction have become a prime focus of contemporary scientific research. The results of this study show significantly fewer streak artifacts when polymer instead of titanium implants are used for midfacial reconstruction. The use of a metallic artifact reduction algorithm (MAR) did not significantly influence artifact occurrence in the presented study. Comparable results were already found for PEEK, PEKK, PPSU as well as polyethylene polymer plates in reconstruction after segmental mandibulectomies [15]. While mandible reconstruction streaks and blooming artifacts were reduced likewise by polymer plates [15], blooming artifacts were not significantly reduced by polymer implants in midfacial reconstruction in the presented study. This can possibly be explained by the smaller diameter of titanium meshes used for midfacial reconstruction compared to mandibular titanium reconstruction plates. More than 20 years ago, Ducic (1997) described the use of a titanium mesh in combination with hydroxyapatite cement for midfacial reconstruction [31]. Yet, the results of the presented study found no significant difference in CT artifacts between titanium meshes and VESTAKEEP iC4800 3DF, a polymer that includes hydroxyapatite. Hence, it can be hypothesized that titanium as well as hydroxyapatite are not ideal materials for midfacial reconstruction after tumor reconstructive surgery. Wei et al. (2017) used expanded polytetrafluoroethylene implants to reconstruct maxillonasal dysplasia with satisfactory clinical results [32]. Recently, there have been many trials which have analyzed the use of resorbable polymer plates in midfacial fractures. Schaller et al. (2018) showed that resorbable polylactide-co-glycolide (PLGA) and magnesium plates offer promising results in midfacial fracture healing [33]. Furthermore, the resorbable properties of PLGA and magnesium plates make plate removal superfluous. The PEEK, PEKK and PPSU polymer implants used in the presented study are non-resorbable and mechanically stable which is beneficial after midfacial reconstruction of boney defects, especially after tumor surgery since defect augmentation is intended to be permanent. Furthermore, the individualized design of the implants improves fitting accuracy [34]. Zhang et al., (2022) used patient-specific PEEK implants for paranasal augmentation of midfacial defects with favorable clinical esthetic outcomes [35]. Park at al. (2016) used polyethylene for paranasal augmentation with good clinical outcome [36].
Postoperative irradiation with or without concomitant chemotherapy is often delivered to patients who undergo surgical tumor resection and successive reconstruction of facial bone structures [37]. Malignant bone invasion is a high-risk factor for local recurrence in most of the different tumor types [38]. Any implanted high-density material may cause CT artifacts, leading to inaccuracy of the radiation dose distribution [11]. A time consuming and imprecise manual water density override is often used to compensate metallic artifact effects [39]. Daily adaptation of the radiation plan with the help of MR-linacs [40] and cone beam CT-based high accuracy systems [41] can improve precise radiation therapy. However, an algorithm providing full automatization of organ segmentation and dose planning is required, which is impaired by metallic artifacts [42]. The well-functioning hardware-based artifact reduction of dual energy CTs will unlikely be implemented in cone beam CT-based radiation therapy systems. Particle therapy is emerging due to its favorable dose delivery outside the target volume. Unfortunately, metallic implants also frequently cause considerable error in proton dosimetry [43]. Most of these challenges could possibly be solved by using polymer implants in patients needing adjuvant radiation therapy. This study showed that oral tissues adjacent to polymer implants in the midface can better be predicted with the correct HU in CT imaging. The presented study used 12 different polymer materials for midfacial augmentation which is a satisfactory amount to conduct a differentiated analysis. However, the limitations of the presented study are the use of a cadaver specimen instead of an actual patient to simulate metallic artifact occurrence. Future trials should demonstrate radiation therapy planning protocols for patients with polymer implants to evaluate the actual effect of these implants on radiation therapy.

5. Conclusions

Personalized polymer implants for midfacial reconstruction significantly reduce metallic artifacts in CT imaging which improves image quality. Hence, postoperative radiation therapy planning as well as radiological tumor aftercare around the implants can be facilitated. Detailed radiation therapy planning protocols with polymer implants need to be established in the future to assess the clinical effect.

Author Contributions

Conceptualization, J.L., L.S., F.R. and A.A.; methodology, J.L. and B.T.; software, A.A. and J.L.; validation, J.L.; formal analysis, J.L., C.S. and L.S.; investigation, J.L.; resources, M.R.; data curation, J.L. and B.T.; writing—original draft preparation, J.L.; writing—review and editing, N.R.K. and W.B.; visualization, J.L. and V.K.; supervision, N.R.K. and W.B.; project administration, J.L.; funding acquisition, A.A., F.R. and J.L. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the Federal Ministry of Education and Research (BMBF) within the project PEEKurious, grant number 13XP5108A.

Institutional Review Board Statement

The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Ethics Committee of Düsseldorf Heinrich-Heine-University (vote: 2020-993).

Informed Consent Statement

Not applicable.

Data Availability Statement

The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.

Conflicts of Interest

Adem Aksu and Frank Reinauer are employed by Karl Leibinger Medizintechnik GmbH & Co. KG (KLM). KLM produces bioresorbable polymer implants.

References

  1. Hinni, M.L.; Ferlito, A.; Brandwein-Gensler, M.S.; Takes, R.P.; Silver, C.E.; Westra, W.H.; Seethala, R.R.; Rodrigo, J.P.; Corry, J.; Bradford, C.R.; et al. Surgical margins in head and neck cancer: A contemporary review. Head Neck 2013, 35, 1362–1370. [Google Scholar] [CrossRef] [PubMed]
  2. Dort, J.C.; Farwell, D.G.; Findlay, M.; Huber, G.F.; Kerr, P.; Shea-Budgell, M.A.; Simon, C.; Uppington, J.; Zygun, D.; Ljungqvist, O.; et al. Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: A consensus review and recommendations from the enhanced recovery after surgery society. JAMA Otolaryngol. Head Neck Surg. 2017, 143, 292–303. [Google Scholar] [CrossRef] [Green Version]
  3. Cramer, J.D.; Burtness, B.; Le, Q.T.; Ferris, R.L. The changing therapeutic landscape of head and neck cancer. Nat. Rev. Clin. Oncol. 2019, 16, 669–683. [Google Scholar] [CrossRef]
  4. Goodson, A.M.; Kittur, M.A.; Evans, P.L.; Williams, E.M. Patient-specific, printed titanium implants for reconstruction of mandibular continuity defects: A systematic review of the evidence. J. Craniomaxillofac. Surg. 2019, 47, 968–976. [Google Scholar] [CrossRef] [PubMed]
  5. Eckstein, F.M.; Zeller, A.N.; Neuhaus, M.T.; Korn, P.; Gellrich, N.C.; Zimmerer, R.M.; Rahlf, B. Referencing for intraoperative navigation: Evaluation of human bias. J. Stomatol. Oral Maxillofac. Surg. 2022, 123, 401–404. [Google Scholar] [CrossRef] [PubMed]
  6. Cotic, M.; Vogt, S.; Hinterwimmer, S.; Feucht, M.J.; Slotta-Huspenina, J.; Schuster, T.; Imhoff, A.B. A matched-pair comparison of two different locking plates for valgus-producing medial open-wedge high tibial osteotomy: Peek-carbon composite plate versus titanium plate. Knee Surg Sports Traumatol. Arthrosc. 2015, 23, 2032–2040. [Google Scholar] [CrossRef] [PubMed]
  7. Fuss, M.; Sturtewagen, E.; De Wagter, C.; Georg, D. Dosimetric characterization of GafChromic EBT film and its implication on film dosimetry quality assurance. Phys. Med. Biol. 2007, 52, 4211–4225. [Google Scholar] [CrossRef]
  8. Paulis, L.E.; Kroll, J.; Heijnens, L.; Huijnen, M.; Gerretsen, R.; Backes, W.H.; Hofman, P.A.M. Is CT bulletproof? On the use of CT for characterization of bullets in forensic radiology. Int. J. Leg. Med. 2019, 133, 1869–1877. [Google Scholar] [CrossRef] [Green Version]
  9. Hünemohr, N.; Krauss, B.; Tremmel, C.; Ackermann, B.; Jäkel, O.; Greilich, S. Experimental verification of ion stopping power prediction from dual energy CT data in tissue surrogates. Phys. Med. Biol. 2014, 59, 83–96. [Google Scholar] [CrossRef]
  10. Glide-Hurst, C.; Chen, D.; Zhong, H.; Chetty, I.J. Changes realized from extended bit-depth and metal artifact reduction in CT. Med. Phys. 2013, 40, 061711. [Google Scholar] [CrossRef]
  11. Spadea, M.F.; Verburg, J.M.; Baroni, G.; Seco, J. The impact of low-Z and high-Z metal implants in IMRT: A Monte Carlo study of dose inaccuracies in commercial dose algorithms. Med. Phys. 2014, 41, 011702. [Google Scholar] [CrossRef] [PubMed]
  12. Laux, C.J.; Villefort, C.; Ehrbar, S.; Wilke, L.; Guckenberger, M.; Müller, D.A. Carbon fiber/polyether ether ketone (CF/PEEK) implants allow for more effective radiation in long bones. Materials 2020, 13, 1754. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Guzzini, M.; Lanzetti, R.M.; Lupariello, D.; Morelli, F.; Princi, G.; Perugia, D.; Ferretti, A. Comparison between carbon-peek plate and conventional stainless steal plate in ankle fractures. A prospective study of two years follow up. Injury 2017, 48, 1249–1252. [Google Scholar] [CrossRef] [PubMed]
  14. Ese, Z.; Zylka, W. Influence of 12-bit and 16-bit CT values of metals on dose calculation in radiotherapy using PRIMO, a Monte Carlo code for clinical linear accelerators. Curr. Dir. Biomed. Eng. 2019, 5, 597–600. [Google Scholar] [CrossRef] [Green Version]
  15. Lommen, J.; Schorn, L.; Sproll, C.; Haussmann, J.; Kübler, N.R.; Budach, W.; Rana, M.; Tamaskovics, B. Reduction of CT artifacts using polyetheretherketone (PEEK), polyetherketoneketone (PEKK), polyphenylsulfone (PPSU), and polyethylene (PE) reconstruction plates in oral oncology. J. Oral Maxillofac. Surg. 2022, 80, 1272–1283. [Google Scholar] [CrossRef] [PubMed]
  16. Lommen, J.; Schorn, L.; Sproll, C.; Kübler, N.R.; Nicolini, L.F.; Merfort, R.; Dilimulati, A.; Hildebrand, F.; Rana, M.; Greven, J. Mechanical fatigue performance of patient-specific polymer plates in oncologic mandible reconstruction. J. Clin. Med. 2022, 11, 3308. [Google Scholar] [CrossRef]
  17. Zanotti, B.; Zingaretti, N.; Verlicchi, A.; Robiony, M.; Alfieri, A.; Parodi, P.C. Cranioplasty: Review of materials. J. Craniofac. Surg. 2016, 27, 2061–2072. [Google Scholar] [CrossRef]
  18. Panayotov, I.V.; Orti, V.; Cuisinier, F.; Yachouh, J. Polyetheretherketone (PEEK) for medical applications. J. Mater. Sci. Mater. Med. 2016, 27, 118. [Google Scholar] [CrossRef]
  19. Nevelsky, A.; Borzov, E.; Daniel, S.; Bar-Deroma, R. Perturbation effects of the carbon fiber-PEEK screws on radiotherapy dose distribution. J. Appl. Clin. Med. Phys. 2017, 18, 62–68. [Google Scholar] [CrossRef]
  20. Neumann, A.; Unkel, C.; Werry, C.; Herborn, C.U.; Maier, H.R.; Ragoß, C.; Jahnke, K. Prototype of a silicon nitride ceramic-based miniplate osteofixation system for the midface. Otolaryngol. Head Neck Surg. 2006, 134, 923–930. [Google Scholar] [CrossRef]
  21. Ma, R.; Tang, T. Current strategies to improve the bioactivity of PEEK. Int. J. Mol. Sci. 2014, 15, 5426–5445. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  22. Le Guevelou, J.; Bastit, V.; Marcy, P.Y.; Lasne-Cardon, A.; Guzene, L.; Gerard, M.; Larnaudie, A.; Coutte, A.; Beddok, A.; Calugaru, V.; et al. Flap delineation guidelines in postoperative head and neck radiation therapy for head and neck cancers. Radiother. Oncol. 2020, 151, 256–265. [Google Scholar] [CrossRef] [PubMed]
  23. Grégoire, V.; Evans, M.; Le, Q.T.; Bourhis, J.; Budach, V.; Chen, A.; Eisbruch, A.; Feng, M.; Giralt, J.; Gupta, T.; et al. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother. Oncol. 2018, 126, 3–24. [Google Scholar]
  24. Barrett, J.F.; Keat, N. Artifacts in CT: Recognition and avoidance. Radiographics 2004, 24, 1679–1691. [Google Scholar] [CrossRef] [PubMed]
  25. Elliott, M.J.; Slakey, J.B. CT provides precise size assessment of implanted titanium alloy pedicle screws. Clin. Orthop. Relat. Res. 2014, 472, 1605–1609. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  26. Kasparek, M.F.; Töpker, M.; Lazar, M.; Weber, M.; Kasparek, M.; Mang, T.; Apfaltrer, P.; Kubista, B.; Windhager, R.; Ringl, H. Dual-energy CT and ceramic or titanium prostheses material reduce CT artifacts and provide superior image quality of total knee arthroplasty. Knee Surg. Sports Traumatol. Arthrosc. 2019, 27, 1552–1561. [Google Scholar] [CrossRef] [Green Version]
  27. Tan, S.; Soulez, G.; Diez Martinez, P.; Larrivée, S.; Stevens, L.M.; Goussard, Y.; Mansour, S.; Chartrand-Lefebvre, C. Coronary stent artifact reduction with an edge-enhancing reconstruction kernel—A prospective cross-sectional study with 256-slice CT. PLoS ONE 2016, 11, e0154292. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  28. Cicchetti, D.V. Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology. Psychol. Assess. 1994, 6, 284. [Google Scholar] [CrossRef]
  29. Koo, T.K.; Li, M.Y. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J. Chiropr. Med. 2016, 15, 155–163. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  30. Wayer, D.R.; Kim, N.Y.; Otto, B.J.; Grayev, A.M.; Kuner, A.D. Unintended consequences: Review of new artifacts introduced by iterative reconstruction CT metal artifact reduction in spine imaging. AJNR Am. J. Neuroradiol. 2019, 40, 1973–1975. [Google Scholar] [CrossRef]
  31. Ducic, Y. Midface reconstruction with titanium mesh and hydroxyapatite cement: A case report. J. Craniomaxillofac. Trauma 1997, 3, 35–39. [Google Scholar]
  32. Wei, J.; Luo, J.; Herrler, T.; Xu, H.; Deng, N.; Li, Q.; Dai, C. A simple technique for the correction of maxillonasal dysplasia using customized expanded polytetrafluoroethylene (ePTFE) implants. J. Plast. Reconstr. Aesthet. Surg. 2017, 70, 1292–1297. [Google Scholar] [CrossRef] [PubMed]
  33. Schaller, B.; Matthias Burkhard, J.P.; Chagnon, M.; Beck, S.; Imwinkelried, T.; Assad, M. Fracture healing and bone remodeling with human standard-sized magnesium versus polylactide-Co-glycolide plate and screw systems using a mini-swine craniomaxillofacial osteotomy fixation model. J. Oral. Maxillofac. Surg. 2018, 76, 2138–2150. [Google Scholar] [CrossRef] [PubMed]
  34. Pang, J.H.; Brooke, S.; Kubik, M.W.; Ferris, R.L.; Dhima, M.; Hanasono, M.M.; Wang, E.W.; Solari, M.G. Staged reconstruction (delayed-immediate) of the maxillectomy defect using CAD/CAM technology. J. Reconstr. Microsurg. 2018, 34, 193–199. [Google Scholar] [CrossRef] [PubMed]
  35. Zhang, J.D.; Li, D.; Liu, Y.M.; Zhang, Z.D.; Fan, Y.D.; Shi, J.D.; Liu, S. Application of patient-specific PEEK implant for aesthetic considerations in paranasal augmentation. J. Craniofac. Surg. 2022, 33, e877–e880. [Google Scholar] [CrossRef] [PubMed]
  36. Park, J.H.; Kim, J.W.; Kim, S.J. Midfacial soft-tissue changes after paranasal augmentation with porous polyethylene. Fac. Plast. Surg. FPS 2016, 32, 232–237. [Google Scholar] [CrossRef] [PubMed]
  37. Furness, S.; Glenny, A.-M.; Worthington, H.V.; Pavitt, S.; Oliver, R.; Clarkson, J.E.; Macluskey, M.; Chan, K.K.; I Conway, D.I. Interventions for the treatment of oral cavity and oropharyngeal cancer: Chemotherapy. Cochrane Database Syst. Rev. 2021, 12, Cd006386. [Google Scholar]
  38. Wang, K.; Zanation, A.M.; Chera, B.S. The role of radiation therapy in the management of sinonasal and ventral skull base malignancies. Otolaryngol. Clin. N. Am. 2017, 50, 419–432. [Google Scholar] [CrossRef]
  39. Wang, X.; Yang, J.N.; Li, X.; Tailor, R.; Vassilliev, O.; Brown, P.; Rhines, L.; Chang, E. Effect of spine hardware on small spinal stereotactic radiosurgery dosimetry. Phys. Med. Biol. 2013, 58, 6733–6747. [Google Scholar] [CrossRef] [PubMed]
  40. Mulder, S.L.; Heukelom, J.; McDonald, B.A.; Van Dijk, L.; Wahid, K.A.; Sanders, K.; Salzillo, T.C.; Hemmati, M.; Schaefer, A.; Fuller, C.D. MR-guided adaptive radiotherapy for OAR sparing in head and neck cancers. Cancers 2022, 14, 1909. [Google Scholar] [CrossRef] [PubMed]
  41. Byrne, M.; Archibald-Heeren, B.; Hu, Y.; Greer, P.; Luo, S.; Aland, T. Assessment of semi-automated stereotactic treatment planning for online adaptive radiotherapy in ethos. Med. Dosim. 2022, 47, 342–347. [Google Scholar] [CrossRef] [PubMed]
  42. Huang, J.Y.; Followill, D.S.; Howell, R.M.; Liu, X.; Mirkovic, D.; Stingo, F.C.; Kry, S.F. Approaches to reducing photon dose calculation errors near metal implants. Med. Phys. 2016, 43, 5117. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  43. Pawałowski, B.; Ryczkowski, A.; Panek, R.; Sobocka-Kurdyk, U.; Graczyk, K.; Piotrowski, T. Accuracy of the doses computed by the Eclipse treatment planning system near and inside metal elements. Sci. Rep. 2022, 12, 5974. [Google Scholar] [CrossRef] [PubMed]
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Figure 1. Segmentation, 3D-reconstruction and virtual planning of the zygomatic implant design. (A–C) Uploading of DICOM data, virtual segmentation and 3D-reconstruction were conducted using the software Individual Patient Solution, IPS Gate® (KLS Martin Group®, Tuttlingen, Germany). Conversion of the 3D virtual model to stereolithography (STL) image files was carried out using Mimics 21.0© (Materialise NV, Leuven, Belgium). (D–F) Defining the zygomatic implant on the left side using a medical modeling software (Geomagic© Freeform Plus© from 3D Systems©, Rock Hill, SC, USA).
Figure 1. Segmentation, 3D-reconstruction and virtual planning of the zygomatic implant design. (A–C) Uploading of DICOM data, virtual segmentation and 3D-reconstruction were conducted using the software Individual Patient Solution, IPS Gate® (KLS Martin Group®, Tuttlingen, Germany). Conversion of the 3D virtual model to stereolithography (STL) image files was carried out using Mimics 21.0© (Materialise NV, Leuven, Belgium). (D–F) Defining the zygomatic implant on the left side using a medical modeling software (Geomagic© Freeform Plus© from 3D Systems©, Rock Hill, SC, USA).
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Figure 2. Display of the 12 different zygomatic polymer implants. Numbered: (1) KU PEKK (KUMOVIS GmbH, Munich, Germany); (2) TE PEEK (Ensinger GmbH, Nufringen, Germany); (3) VK iC4800 (EVONIK Industries AG, Essen, Germany); (4) VVK i4 (EVONIK Industries AG, Essen, Germany); (5) Radel PPSU (Solvay GmbH, Hanover, Germany); (6) VK A1 (EVONIK Industries AG, Essen, Germany); (7) VK A2 (EVONIK Industries AG, Essen, Germany); (8) PEKK nature (PEKK Filament, KUMOVIS GmbH, Munich, Germany); (9) VK A3 (EVONIK Industries AG, Essen, Germany); (10) VK B1 (EVONIK Industries AG, Essen, Germany); (11) VK B2 (EVONIK Industries AG, Essen, Germany); (12) VK B3 (EVONIK Industries AG, Essen, Germany).
Figure 2. Display of the 12 different zygomatic polymer implants. Numbered: (1) KU PEKK (KUMOVIS GmbH, Munich, Germany); (2) TE PEEK (Ensinger GmbH, Nufringen, Germany); (3) VK iC4800 (EVONIK Industries AG, Essen, Germany); (4) VVK i4 (EVONIK Industries AG, Essen, Germany); (5) Radel PPSU (Solvay GmbH, Hanover, Germany); (6) VK A1 (EVONIK Industries AG, Essen, Germany); (7) VK A2 (EVONIK Industries AG, Essen, Germany); (8) PEKK nature (PEKK Filament, KUMOVIS GmbH, Munich, Germany); (9) VK A3 (EVONIK Industries AG, Essen, Germany); (10) VK B1 (EVONIK Industries AG, Essen, Germany); (11) VK B2 (EVONIK Industries AG, Essen, Germany); (12) VK B3 (EVONIK Industries AG, Essen, Germany).
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Figure 3. Display of the zygomatic implant design with five different thicknesses (top left 2.58 mm, top right 3.04 mm, center 4.65 mm, left bottom 3.02 mm, right bottom 2.80 mm).
Figure 3. Display of the zygomatic implant design with five different thicknesses (top left 2.58 mm, top right 3.04 mm, center 4.65 mm, left bottom 3.02 mm, right bottom 2.80 mm).
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Figure 4. Axial view of selection of three circular regions of interest (ROI) in close proximity to the zygomatic implant using the ROI manager in ImageJ [(1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland]. Plugins used were CT Window Level and SPICE-CT Package for Computed Tomography QC (Loveland, J.; 2011). HU window was set to soft tissue. Mean HU values were measured for all ROI to determine artifact occurrence.
Figure 4. Axial view of selection of three circular regions of interest (ROI) in close proximity to the zygomatic implant using the ROI manager in ImageJ [(1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland]. Plugins used were CT Window Level and SPICE-CT Package for Computed Tomography QC (Loveland, J.; 2011). HU window was set to soft tissue. Mean HU values were measured for all ROI to determine artifact occurrence.
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Figure 5. Streak artifacts of TM, VK iC4800, KU PEKK, VK i4, Radel PPSU, PEKK nature and TE PEEK in CT images in axial orientation versus control. Artifacts of each implant were measured at three different anatomical landmarks: (1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland.
Figure 5. Streak artifacts of TM, VK iC4800, KU PEKK, VK i4, Radel PPSU, PEKK nature and TE PEEK in CT images in axial orientation versus control. Artifacts of each implant were measured at three different anatomical landmarks: (1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland.
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Figure 6. Streak artifacts VK A1, VK A2, VK A3, VK B1, VK B2 and VK B3 in CT images in axial orientation versus control. Artifacts of each implant were measured at three different anatomical landmarks: (1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland.
Figure 6. Streak artifacts VK A1, VK A2, VK A3, VK B1, VK B2 and VK B3 in CT images in axial orientation versus control. Artifacts of each implant were measured at three different anatomical landmarks: (1) the zygomatic soft tissue, (2) the temporal muscle and (3) the parotid gland.
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Figure 7. Boxplots of mean Hounsfield Unit (HU) values for all 12 polymer implants (VK iC4800; KU PEKK; VK i4; Radel PPSU; PEKK nature; TE PEEK; VK A1; VK A2; VK A3; VK B1; VK B2; VK B3), TM and control. Mean values are provided in Table 2.
Figure 7. Boxplots of mean Hounsfield Unit (HU) values for all 12 polymer implants (VK iC4800; KU PEKK; VK i4; Radel PPSU; PEKK nature; TE PEEK; VK A1; VK A2; VK A3; VK B1; VK B2; VK B3), TM and control. Mean values are provided in Table 2.
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Table
Table 1. List of all implant material names, abbreviations and manufacturers.
Table 1. List of all implant material names, abbreviations and manufacturers.
Implant MaterialAbbreviationManufacturer
Titanium MeshTMKLS Martin Group®, Tuttlingen, Germany
VESTAKEEP iC4800 3DFVK iC4800EVONIK Industries AG, Essen, Germany
KUMOVIS PEKK WHITEKU PEKKKUMOVIS GmbH, Munich, Germany
VESTAKEEP i4 3DFVK i4EVONIK Industries AG, Essen, Germany
Radel PPSU AM MSNT1Radel PPSUSolvay GmbH, Hannover, Germany
PEKK naturePEKK natureKUMOVIS GmbH, Munich, Germany
TECAFIL PEEK VX CFTE PEEKEnsinger GmbH, Nufringen, Germany
VESTAKEEP CF Filament-Fiber A1VK A1EVONIK Industries AG, Essen, Germany
VESTAKEEP CF Filament-Fiber A2VK A2EVONIK Industries AG, Essen, Germany
VESTAKEEP CF Filament-Fiber A3VK A3EVONIK Industries AG, Essen, Germany
VESTAKEEP CF Filament-Fiber B1VK B1EVONIK Industries AG, Essen, Germany
VESTAKEEP CF Filament-Fiber B2VK B2EVONIK Industries AG, Essen, Germany
VESTAKEEP CF Filament-Fiber B3VK B3EVONIK Industries AG, Essen, Germany
Table
Table 2. Display of implant materials, mean standard deviation of Hounsfield Units (HU) and their difference to control as well as respective p-values.
Table 2. Display of implant materials, mean standard deviation of Hounsfield Units (HU) and their difference to control as well as respective p-values.
Implant MaterialAbbreviationMean Standard Deviation (HU)Differenceap-Valuea
Titanium MeshTM173.7 (±5.1)121.3 (±5.4)<0.001 *
VESTAKEEP iC4800 3DFVK iC4800155.3 (±5.9)103.0 (±4.2)0.007 *
KUMOVIS PEKK WHITEKU PEKK80.7 (±7.4)28.3 (±8.5)0.084
VESTAKEEP i4 3DFVK i474.7 (±5.5)22.3 (±6.2)0.123
Radel PPSU AM MSNT1Radel PPSU75.7 (±5.0)23.3 (±7.4)0.125
PEKK naturePEKK nature77.0 (±5.3)24.7 (±3.3)0.110
TECAFIL PEEK VX CFTE PEEK74.7 (±6.0)22.3 (±4.3)0.125
VESTAKEEP CF Filament-Fiber A1VK A163.3 (±5.9)11.0 (±2.4)0.213
VESTAKEEP CF Filament-Fiber A2VK A280.3 (±5.0)28.0 (±6.1)0.085
VESTAKEEP CF Filament-Fiber A3VK A368.0 (±7.5)15.7 (±3.3)0.151
VESTAKEEP CF Filament-Fiber B1VK B164.7 (±6.7)12.3 (±3.9)0.164
VESTAKEEP CF Filament-Fiber B2VK B262.3 (±7.6)10.0 (±2.8)0.243
VESTAKEEP CF Filament-Fiber B3VK B366.0 (±9.5)13.7 (±3.1)0.155
a compared to control; * significance level 0.05.
Table
Table 3. Display of implant materials, comparison of real implant diameter (mm) and CT diameter (mm) as virtual growth (mm) with respective p-values and image quality.
Table 3. Display of implant materials, comparison of real implant diameter (mm) and CT diameter (mm) as virtual growth (mm) with respective p-values and image quality.
Implant MaterialAbbreviationReal Diameter (mm)CT Diameter (mm)Virtual Growth (mm)p ValueImage Qualitya
Titanium MeshTM0.450.5 (±0.5)0.05 (±0.5)0.9872
VESTAKEEP iC4800 3DFVK iC48004.654.8 (±0.2)0.15 (±0.2)0.9562
KUMOVIS PEKK WHITEKU PEKK4.654.8 (±0.3)0.15 (±0.3)0.9562
VESTAKEEP i4 3DFVK i44.654.7 (±0.1)0.05 (±0.1)0.9871
Radel PPSU AM MSNT1Radel PPSU4.654.7 (±0.1)0.05 (±0.1)0.9872
PEKK naturePEKK nature4.654,9 (±0.2)0.25 (±0.2)0.9322
TECAFIL PEEK VX CFTE PEEK4.654.7 (±0.1)0.05 (±0.1)0.9871
VESTAKEEP CF Filament-Fiber A1VK A14.654.8 (±0.1)0.15 (±0.1)0.9562
VESTAKEEP CF Filament-Fiber A2VK A24.654.7 (±0.2)0.05 (±0.2)0.9872
VESTAKEEP CF Filament-Fiber A3VK A34.654.9 (±0.4)0.25 (±0.4)0.9322
VESTAKEEP CF Filament-Fiber B1VK B14.654.8 (±0.2)0.15 (±0.2)0.9562
VESTAKEEP CF Filament-Fiber B2VK B24.654.9 (±0.1)0.25 (±0.1)0.9321
VESTAKEEP CF Filament-Fiber B3VK B34.654.7 (±0.1)0.05 (±0.1)0.9871
a Five-point Likert scale with median ranking (1–5; 1 = very good; 2 = good; 3 = intermediate; 4 = bad; 5 = very bad).
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MDPI and ACS Style

Lommen, J.; Schorn, L.; Sproll, C.; Kerkfeld, V.; Aksu, A.; Reinauer, F.; Kübler, N.R.; Budach, W.; Rana, M.; Tamaskovics, B. Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality. J. Pers. Med. 2023, 13, 236. https://doi.org/10.3390/jpm13020236

AMA Style

Lommen J, Schorn L, Sproll C, Kerkfeld V, Aksu A, Reinauer F, Kübler NR, Budach W, Rana M, Tamaskovics B. Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality. Journal of Personalized Medicine. 2023; 13(2):236. https://doi.org/10.3390/jpm13020236

Chicago/Turabian Style

Lommen, Julian, Lara Schorn, Christoph Sproll, Valentin Kerkfeld, Adem Aksu, Frank Reinauer, Norbert R. Kübler, Wilfried Budach, Majeed Rana, and Bálint Tamaskovics. 2023. "Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality" Journal of Personalized Medicine 13, no. 2: 236. https://doi.org/10.3390/jpm13020236

APA Style

Lommen, J., Schorn, L., Sproll, C., Kerkfeld, V., Aksu, A., Reinauer, F., Kübler, N. R., Budach, W., Rana, M., & Tamaskovics, B. (2023). Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality. Journal of Personalized Medicine, 13(2), 236. https://doi.org/10.3390/jpm13020236

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