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Article
Peer-Review Record

Safety and Efficacy of Autologous Stem Cell Treatment for Facetogenic Chronic Back Pain

J. Pers. Med. 2023, 13(3), 436; https://doi.org/10.3390/jpm13030436
by Ralf Rothoerl 1, Junee Tomelden 1 and Eckhard Udo Alt 1,2,*
Reviewer 1:
Reviewer 2: Anonymous
J. Pers. Med. 2023, 13(3), 436; https://doi.org/10.3390/jpm13030436
Submission received: 30 January 2023 / Revised: 14 February 2023 / Accepted: 17 February 2023 / Published: 28 February 2023
(This article belongs to the Section Clinical Medicine, Cell, and Organism Physiology)

Round 1

Reviewer 1 Report

This study is very interesting and the use of  Unmodified Adipose Tissue Derived Regenerative Cells (ADRC) it is a promising application for facetogenic chronic back pain.  In the light of evidence that the adipose tissue was enzymatically manipulated by The Matrase Reagent (enzyme blend of collagenase and neutral protease) AA should clarify if this treatment is considered advanced therapy medicinal products (ATMPs)  for The European Medicine Agency and the U.S. Food and Drug Admin- istration (FDA)

Author Response

Dear reviewer pleas find enclosed our revised manuscript.

Best regards

Ralf Rothörl

Reviewer 2 Report

Minor

1 Please list the basic information of included patient with the clinical efficacy

2 Please defined “adipose tissue derived regenerative cells”. Mesenchymal stem cells? Vascular cells? Neuronal cells? Or mixture of them?

 Author Response

Dear reviewer pleas find enclosed our revised manuscript.

Best regards

Ralf Rothörl

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