Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Data Source
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Demographic Features | |
Age, years, mean (SD) | 67.3 (11.6) |
Gender, male, no. (%) | 95 (54.6) |
BMI, mean (SD) | 27.0 (5.8) |
Neck circumference, cm, mean (SD) | 40.7 (4.6) |
Respiratory Indices | |
O-AHI, mean (SD) | 17.9 (19.0) |
C-AHI, mean (SD) | 4.4 (6.7) |
ODI, mean (SD) | 20.7 (20.5) |
Clinical Features | |
OSA, no. (%) | 89 (51.2) |
Atrial fibrillation, no. (%) | 55 (31.6) |
Hypertension, no. (%) | 126 (72.4) |
Diabetes, no. (%) | 53 (30.5) |
Dyslipidemia, no. (%) | 76 (43.7) |
Reperfusion therapy, no. (%) | 38 (21.8) |
NIHSS, mean (SD) | 8.8 (6.8) |
Dysphagia, no. (%) | 92 (52.9) |
Pneumonia, no. (%) | 10 (5.7) |
Death, no. (%) | 2 (1.1) |
Wake-up stroke, no. (%) | 50 (28.7) |
OCSP | |
TACI, no. (%) | 42 (24.1) |
PACI, no. (%) | 81 (46.6) |
LACI, no. (%) | 20 (11.5) |
POCI, no. (%) | 31 (17.8) |
TOAST | |
Cardioembolism, no. (%) | 66 (37.9) |
Large Artery Atherosclerosis, no. (%) | 28 (16.1) |
Small Vessel Occlusion, no. (%) | 25 (14.4) |
Other Determined Origin, no. (%) | 4 (2.3) |
Stroke of Undetermined Etiology, no. (%) | 51 (29.3) |
OSA+ (n = 89) | OSA− (n = 85) | Mann–Whitney U | χ2 | p | |
---|---|---|---|---|---|
Demographic features | |||||
Age, years, mean (SD) | 68.6 (11.0) | 66.0 (12.2) | 4229.5 | 0.178 | |
Gender, male, no. (%) | 49 (55.1) | 46 (54.1) | 0.015 | 0.901 | |
BMI, mean (SD) | 28.4 (6.6) | 25.9 (4.7) | 2792.5 | 0.001 | |
Neck circumference, cm, mean (SD) | 42.3 (4.3) | 39.4 (4.4) | 2921.0 | <0.001 | |
C-AHI, mean (SD) | 5.6 (7.2) | 3.2 (6.1) | 4250.0 | 0.028 | |
O-AHI, mean (SD) | 31.8 (17.7) | 3.7 (2.9) | |||
ODI, mean (SD) | 34.7 (19.8) | 6.6 (7.2) | |||
Clinical features | |||||
Atrial fibrillation, no. (%) | 33 (37.1) | 22 (25.9) | 2.521 | 0.112 | |
Hypertension, no. (%) | 76 (85.4) | 50 (58.8) | 17.866 | <0.001 | |
Diabetes, no. (%) | 33 (37.1) | 20 (23.5) | 3.778 | 0.052 | |
Dyslipidemia, no. (%) | 40 (44.9) | 36 (42.4) | 0.040 | 0.842 | |
Reperfusion therapy, no. (%) | 22 (24.7) | 16 (18.8) | 0.262 | 0.609 | |
NIHSS, mean (SD) | 9.3 (6.8) | 8.3 (6.9) | 4128.5 | 0.296 | |
Dysphagia, no. (%) | 59 (66.3) | 33 (38.8) | 13.165 | <0.001 | |
Pneumonia, no. (%) | 7 (7.9) | 3 (3.5) | 0.963 | 0.327 | |
Death, no. (%) | 2 (2.2) | 0 (0.0) | 1.701 | 0.192 | |
Wake-up stroke, no. (%) | 24 (27.0) | 26 (30.6) | 0.279 | 0.359 | |
OCSP | 1.944 | 0.584 | |||
TACI, no. (%) | 25 (28.1) | 17 (20.0) | |||
PACI, no. (%) | 39 (43.8) | 41 (48.2) | |||
LACI, no. (%) | 9 (10.1) | 12 (14.1) | |||
POCI, no. (%) | 16 (18.0) | 15 (16.9) | |||
TOAST | 3.468 | 0.483 | |||
Cardioembolism, no. (%) | 37 (56.1) | 29 (43.9) | |||
Large Artery Atherosclerosis, no. (%) | 14 (50.0) | 14 (50.0) | |||
Small Vessel Occlusion, no. (%) | 15 (60.0) | 10 (40.0) | |||
Other Determined Origin, no. (%) | 2 (50.0) | 2 (50.0) | |||
Stroke of Undetermined Etiology, no. (%) | 21 (41.2) | 30 (58.8) |
Odds Ratio | 95% Confidence Interval | p | ||
---|---|---|---|---|
Lower | Upper | |||
Age | 1.011 | 0.960 | 1.064 | 0.684 |
Gender (Male) | 0.443 | 0.151 | 1.298 | 0.138 |
BMI | 1.182 | 1.032 | 1.353 | 0.016 |
Neck Circumference | 1.116 | 0.965 | 1.290 | 0.138 |
Wake-up stroke | 0.744 | 0.266 | 2.083 | 0.574 |
NIHSS | 0.941 | 0.856 | 1.034 | 0.208 |
Dysphagia | 6.945 | 1.964 | 24.552 | 0.003 |
Hypertension | 5.349 | 1.465 | 19.534 | 0.011 |
Diabetes | 1.437 | 0.493 | 4.186 | 0.506 |
Atrial Fibrillation | 0.861 | 0.279 | 2.657 | 0.795 |
C-AHI | 1.037 | 0.959 | 1.120 | 0.364 |
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Brunetti, V.; Testani, E.; Losurdo, A.; Vollono, C.; Broccolini, A.; Di Iorio, R.; Frisullo, G.; Pilato, F.; Profice, P.; Marotta, J.; et al. Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study. J. Pers. Med. 2023, 13, 527. https://doi.org/10.3390/jpm13030527
Brunetti V, Testani E, Losurdo A, Vollono C, Broccolini A, Di Iorio R, Frisullo G, Pilato F, Profice P, Marotta J, et al. Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study. Journal of Personalized Medicine. 2023; 13(3):527. https://doi.org/10.3390/jpm13030527
Chicago/Turabian StyleBrunetti, Valerio, Elisa Testani, Anna Losurdo, Catello Vollono, Aldobrando Broccolini, Riccardo Di Iorio, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Jessica Marotta, and et al. 2023. "Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study" Journal of Personalized Medicine 13, no. 3: 527. https://doi.org/10.3390/jpm13030527