State of the Art and Challenges in Epilepsy—A Narrative Review

Manole, Aida Mihaela; Sirbu, Carmen Adella; Mititelu, Mihaela Raluca; Vasiliu, Octavian; Lorusso, Lorenzo; Sirbu, Octavian Mihai; Ionita Radu, Florentina

doi:10.3390/jpm13040623

Open AccessEditor’s ChoiceReview

State of the Art and Challenges in Epilepsy—A Narrative Review

by

Aida Mihaela Manole

^1,†,

Carmen Adella Sirbu

^2,3,†

,

Mihaela Raluca Mititelu

^4,5,*

,

Octavian Vasiliu

⁶,

Lorenzo Lorusso

⁷

,

Octavian Mihai Sirbu

^2,8,* and

Florentina Ionita Radu

^9,10

¹

Department of Neurology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242 Bucharest, Romania

²

Clinical Neurosciences Department, University of Medicine and Pharmacy “Carol Davila” Bucharest, 050474 Bucharest, Romania

³

Centre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), Department of Neurology, Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania

⁴

Nuclear Medicine Department, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242 Bucharest, Romania

⁵

Department No.8, University of Medicine and Pharmacy “Carol Davila” Bucharest, 050474 Bucharest, Romania

⁶

Department of Psychiatry, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242, Bucharest, Romania

⁷

Neurology Unit—Neuroscience Dept. A.S.S.T.Lecco, Merate Hospital, 23807 Merate, Italy

⁸

Department of Neurosurgery, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010242 Bucharest, Romania

⁹

Department of Gastroenterology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania

¹⁰

Department of Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this study.

J. Pers. Med. 2023, 13(4), 623; https://doi.org/10.3390/jpm13040623

Submission received: 23 February 2023 / Revised: 18 March 2023 / Accepted: 29 March 2023 / Published: 1 April 2023

(This article belongs to the Special Issue Epilepsy: Pathogenesis, Treatment, and Precision Medicine)

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Abstract

Epilepsy is a common condition worldwide, with approximately 50 million people suffering from it. A single seizure does not mean epilepsy; almost 10% of the population can have a seizure during their lifetime. In particular, there are many other central nervous system disorders other than epilepsy in which seizures occur, either transiently or as a comorbid condition. The impact of seizures and epilepsy is, therefore, widespread and easily underestimated. It is estimated that about 70% of patients with epilepsy could be seizure-free if correctly diagnosed and treated. However, for patients with epilepsy, quality of life is influenced not only by seizure control but also by antiepileptic drug-adverse reactions, access to education, mood, employment, and transportation.

Keywords: seizure; seizure-free; quality of life; epilepsy; education; drug-resistant; medically intractable; pharmacoresistant; surgery; neurosurgery

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MDPI and ACS Style

Manole, A.M.; Sirbu, C.A.; Mititelu, M.R.; Vasiliu, O.; Lorusso, L.; Sirbu, O.M.; Ionita Radu, F. State of the Art and Challenges in Epilepsy—A Narrative Review. J. Pers. Med. 2023, 13, 623. https://doi.org/10.3390/jpm13040623

AMA Style

Manole AM, Sirbu CA, Mititelu MR, Vasiliu O, Lorusso L, Sirbu OM, Ionita Radu F. State of the Art and Challenges in Epilepsy—A Narrative Review. Journal of Personalized Medicine. 2023; 13(4):623. https://doi.org/10.3390/jpm13040623

Chicago/Turabian Style

Manole, Aida Mihaela, Carmen Adella Sirbu, Mihaela Raluca Mititelu, Octavian Vasiliu, Lorenzo Lorusso, Octavian Mihai Sirbu, and Florentina Ionita Radu. 2023. "State of the Art and Challenges in Epilepsy—A Narrative Review" Journal of Personalized Medicine 13, no. 4: 623. https://doi.org/10.3390/jpm13040623

APA Style

Manole, A. M., Sirbu, C. A., Mititelu, M. R., Vasiliu, O., Lorusso, L., Sirbu, O. M., & Ionita Radu, F. (2023). State of the Art and Challenges in Epilepsy—A Narrative Review. Journal of Personalized Medicine, 13(4), 623. https://doi.org/10.3390/jpm13040623

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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State of the Art and Challenges in Epilepsy—A Narrative Review

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