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Volume 14
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10.3390/jpm14070702
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Systematic Review

Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature

by
Stefan Milutinovic
1,
Abraham Bell
1,
Predrag Jancic
2,*,
Dragana Stanojevic
3,
Abdul Hamid Borghol
4,
Jonathan Mina
5,
Fouad T. Chebib
4,
Ibrahim Khambati
6,
Ricardo O. Escarcega
1,7 and
Malissa J. Wood
7
1
Internal Medicine Residency Program at Lee Health, Florida State University College of Medicine, Cape Coral, FL 33909, USA
2
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
3
Clinic for Cardiology, University Clinical Center Nis, 18000 Nis, Serbia
4
Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, USA
5
Department of Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY 10305, USA
6
Associates in Nephrology, Cape Coral, FL 33909, USA
7
Lee Health Heart Institute, Fort Myers, FL 33908, USA
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2024, 14(7), 702; https://doi.org/10.3390/jpm14070702
Submission received: 5 June 2024 / Revised: 17 June 2024 / Accepted: 26 June 2024 / Published: 29 June 2024
(This article belongs to the Section Clinical Medicine, Cell, and Organism Physiology)
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Abstract

Spontaneous coronary artery dissection (SCAD) is a spontaneous intimal tear of the coronary artery wall. A factor rarely associated with SCAD is autosomal dominant polycystic kidney disease (ADPKD). Using the PRISMA guidelines, we identified 10 unique cases of SCAD in ADPKD patients reported between 1998 and 2021. Ages ranged from 36 to 59 years, with an average of 44.6 years. The majority of patients were female (80%). Each case was diagnosed with a cardiovascular event: ST-elevation myocardial infarction (STEMI) in 40%, non-ST elevation myocardial infarction (NSTEMI) in 50%, and stable angina in 10%. Conservative management was used in 60% of cases. There is a significant gap in our understanding of the relationship between SCAD and ADPKD. Polycystin complex can lead to structural abnormalities in blood vessels, resulting in vascular leaks and vessel rupture. This suggests that ADPKD patients may have an elevated risk of arteriopathies, including coronary artery dissection.
Keywords: SCAD; ADPKD; polycystin; vascular integrity SCAD; ADPKD; polycystin; vascular integrity

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MDPI and ACS Style

Milutinovic, S.; Bell, A.; Jancic, P.; Stanojevic, D.; Borghol, A.H.; Mina, J.; Chebib, F.T.; Khambati, I.; Escarcega, R.O.; Wood, M.J. Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature. J. Pers. Med. 2024, 14, 702. https://doi.org/10.3390/jpm14070702

AMA Style

Milutinovic S, Bell A, Jancic P, Stanojevic D, Borghol AH, Mina J, Chebib FT, Khambati I, Escarcega RO, Wood MJ. Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature. Journal of Personalized Medicine. 2024; 14(7):702. https://doi.org/10.3390/jpm14070702

Chicago/Turabian Style

Milutinovic, Stefan, Abraham Bell, Predrag Jancic, Dragana Stanojevic, Abdul Hamid Borghol, Jonathan Mina, Fouad T. Chebib, Ibrahim Khambati, Ricardo O. Escarcega, and Malissa J. Wood. 2024. "Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature" Journal of Personalized Medicine 14, no. 7: 702. https://doi.org/10.3390/jpm14070702

APA Style

Milutinovic, S., Bell, A., Jancic, P., Stanojevic, D., Borghol, A. H., Mina, J., Chebib, F. T., Khambati, I., Escarcega, R. O., & Wood, M. J. (2024). Spontaneous Coronary Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review of the Literature. Journal of Personalized Medicine, 14(7), 702. https://doi.org/10.3390/jpm14070702

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