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Open AccessReview
Fundus Autofluorescence in Diabetic Retinopathy
by
Otilia-Maria Dumitrescu
Otilia-Maria Dumitrescu 1,†,
Mihail Zemba
Mihail Zemba 1,2,*,
Daniel Constantin Brănișteanu
Daniel Constantin Brănișteanu 3,†
,
Ruxandra Angela Pîrvulescu
Ruxandra Angela Pîrvulescu 2,†
,
Madalina Radu
Madalina Radu 1 and
Horia Tudor Stanca
Horia Tudor Stanca 2
1
Department of Ophthalmology, “Dr. Carol Davila” Central Military Emergency University Hospital, 010825 Bucharest, Romania
2
Department of Ophthalmology, University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania
3
Department of Ophthalmology, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2024, 14(8), 793; https://doi.org/10.3390/jpm14080793 (registering DOI)
Submission received: 23 June 2024
/
Revised: 18 July 2024
/
Accepted: 24 July 2024
/
Published: 26 July 2024
Abstract
Diabetic retinopathy is a leading cause of visual morbidity worldwide. Fundus autofluorescence is a rapid, non-invasive imaging modality that has gained increased popularity in recent years in the multimodal evaluation of diabetic retinopathy and, in particular, of diabetic macular oedema. Acquired using either a fundus camera or the confocal scanning laser ophthalmoscope, short-wavelength and near-infrared autofluorescence are the most used techniques in diabetic retinopathy. In diabetic macular oedema, short-wavelength autofluorescence, in its cystoid pattern, is useful for detecting cystoid macular oedema. Increased spot hyperautofluorescence in short-wavelength and granular changes in near-infrared autofluorescence correlate well with other imaging findings, indicating photoreceptor and retinal pigment epithelium damage and being associated with decreased visual acuity. While also being a marker of oxidative stress, increased short-wavelength autofluorescence in the setting of diabetic macular oedema appears to be a prognostic factor for poor visual outcome, even after the resolution of the intraretinal fluid. Autofluorescence also helps in the assessment of diabetic retinal pigment epitheliopathy and choroidopathy. Fundus autofluorescence is an evolving technology that will assist in gaining further insight into the pathophysiology of diabetic retinopathy and allow for a more comprehensive evaluation of these patients.
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MDPI and ACS Style
Dumitrescu, O.-M.; Zemba, M.; Brănișteanu, D.C.; Pîrvulescu, R.A.; Radu, M.; Stanca, H.T.
Fundus Autofluorescence in Diabetic Retinopathy. J. Pers. Med. 2024, 14, 793.
https://doi.org/10.3390/jpm14080793
AMA Style
Dumitrescu O-M, Zemba M, Brănișteanu DC, Pîrvulescu RA, Radu M, Stanca HT.
Fundus Autofluorescence in Diabetic Retinopathy. Journal of Personalized Medicine. 2024; 14(8):793.
https://doi.org/10.3390/jpm14080793
Chicago/Turabian Style
Dumitrescu, Otilia-Maria, Mihail Zemba, Daniel Constantin Brănișteanu, Ruxandra Angela Pîrvulescu, Madalina Radu, and Horia Tudor Stanca.
2024. "Fundus Autofluorescence in Diabetic Retinopathy" Journal of Personalized Medicine 14, no. 8: 793.
https://doi.org/10.3390/jpm14080793
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