Next Article in Journal
How Does Nerve Mechanical Interface Treatment Impact Pre-Surgical Carpal Tunnel Syndrome Patients? A Randomized Controlled Trial
Previous Article in Journal
Long COVID Is Not a Functional Neurologic Disorder
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JPM
Volume 14
Issue 8
10.3390/jpm14080800
jpm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Systematic Review

The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review

by
Patrick Mandal
1,*,†,
Maximilian Moshammer
1,2,†,
Andrzej Hecker
1,2,
Christian Smolle
1,
Martina Carnieletto
1,
Marcel Mayrhofer
1,
Michael Schintler
1,
Raimund Winter
1 and
Lars Peter Kamolz
1,2
1
Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 34/4, 8010 Graz, Austria
2
COREMED—Centre for Regenerative Medicine and Precisions Medicine, Neue Stiftingtalstrasse 2, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2024, 14(8), 800; https://doi.org/10.3390/jpm14080800
Submission received: 29 June 2024 / Revised: 25 July 2024 / Accepted: 26 July 2024 / Published: 29 July 2024
(This article belongs to the Section Regenerative Medicine and Therapeutics)
Browse Figures
Versions Notes

Abstract

Background: Microvascular thrombosis following free tissue transfer presents a complex challenge for surgeons and carries the potential risk of flap failure. The application of fibrinolytic agents represents a robust therapeutic option. The aim of this systematic review is to provide a comprehensive overview of the clinical use of fibrinolytic drugs in the rescue of compromised free flaps. Methods: A systematic literature search for clinical studies detailing the utilization of fibrinolytic agents for salvaging free flaps was conducted using the PubMed and Web of Science databases. The inclusion criteria encompassed English-language publications that specifically addressed the clinical application of fibrinolytic agents for free-flap salvage. Results: A total of 331 articles were screened after excluding duplicates, with 56 meeting the inclusion criteria. Among these, 21 were clinical trials (evidence level III), and 35 were case studies (evidence level IV/V). In total, 459 flaps underwent treatment with fibrinolytic agents. Conclusion: The application of fibrinolytic agents appears to be a valuable intervention for rescuing compromised free flaps attributable to microvascular compromise. Notably, no prospective randomized trials have been published on this subject, and the evidence within the existing literature is characterized by its limited and heterogeneous nature. Further research is imperative to gather data on the efficacy, dosage, and safety profile of fibrinolytic agents.
Keywords: fibrinolytic agents; free-flap; salvage; microvascular compromise fibrinolytic agents; free-flap; salvage; microvascular compromise

Share and Cite

MDPI and ACS Style

Mandal, P.; Moshammer, M.; Hecker, A.; Smolle, C.; Carnieletto, M.; Mayrhofer, M.; Schintler, M.; Winter, R.; Kamolz, L.P. The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review. J. Pers. Med. 2024, 14, 800. https://doi.org/10.3390/jpm14080800

AMA Style

Mandal P, Moshammer M, Hecker A, Smolle C, Carnieletto M, Mayrhofer M, Schintler M, Winter R, Kamolz LP. The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review. Journal of Personalized Medicine. 2024; 14(8):800. https://doi.org/10.3390/jpm14080800

Chicago/Turabian Style

Mandal, Patrick, Maximilian Moshammer, Andrzej Hecker, Christian Smolle, Martina Carnieletto, Marcel Mayrhofer, Michael Schintler, Raimund Winter, and Lars Peter Kamolz. 2024. "The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review" Journal of Personalized Medicine 14, no. 8: 800. https://doi.org/10.3390/jpm14080800

APA Style

Mandal, P., Moshammer, M., Hecker, A., Smolle, C., Carnieletto, M., Mayrhofer, M., Schintler, M., Winter, R., & Kamolz, L. P. (2024). The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review. Journal of Personalized Medicine, 14(8), 800. https://doi.org/10.3390/jpm14080800

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop