Abstract
Introduction: Radiotherapy (RT) shows potential for improving local control in cases of oligoprogressive metastatic breast cancer (mBC). This retrospective analysis aims to evaluate the advantages of RT in such a clinical scenario. Methods: We conducted a retrospective analysis including patients with mBC who received radiation therapy (RT) for up to three sites of oligoprogression while continuing systemic therapy. The study took place between January 2014 and December 2021. Our endpoints were progression-free survival after radiotherapy (PFS-AR), the rate of discontinuation of systemic therapy (RDT) at three months post-RT, and overall survival (OS). We used Cox regression analysis to perform multivariate analysis for PFS-AR. Results: Fifty-nine patients met the inclusion criteria. The PFS-AR was 13 months (95% CI 8.5–18.8 months). At three months, the RDT was 3% (two patients). A significant difference in median PFS-AR was observed between patients in the first + second-line group and those in the subsequent line group (p = 0.03). In the multivariate analysis conducted for PFS-AR, the biologically effective dose (BED) with α/β = 4 > 100 Gy emerged as the sole significant variable (p = 0.0017). The median overall survival (OS) was 24.4 months (95% CI 17–24.4 months). Conclusions: This study is the first report on the outcomes of radiotherapy in a cohort of over 50 patients with oligoprogressive metastatic breast cancer (mBC). Our findings emphasize the significant relationship between PFS-AR, the number of ongoing lines of systemic therapy, and the BED of radiotherapy.
Share and Cite
MDPI and ACS Style
Marazzi, F.; Masiello, V.; Orlandi, A.; Moschella, F.; Chiesa, S.; Di Leone, A.; Garufi, G.; Mazzarella, C.; Sanchez, A.M.; Casa, C.;
et al. Outcomes of Radiotherapy in Oligoprogressive Breast Cancer. J. Pers. Med. 2024, 14, 805.
https://doi.org/10.3390/jpm14080805
AMA Style
Marazzi F, Masiello V, Orlandi A, Moschella F, Chiesa S, Di Leone A, Garufi G, Mazzarella C, Sanchez AM, Casa C,
et al. Outcomes of Radiotherapy in Oligoprogressive Breast Cancer. Journal of Personalized Medicine. 2024; 14(8):805.
https://doi.org/10.3390/jpm14080805
Chicago/Turabian Style
Marazzi, Fabio, Valeria Masiello, Armando Orlandi, Francesca Moschella, Silvia Chiesa, Alba Di Leone, Giovanna Garufi, Ciro Mazzarella, Alejandro M. Sanchez, Calogero Casa,
and et al. 2024. "Outcomes of Radiotherapy in Oligoprogressive Breast Cancer" Journal of Personalized Medicine 14, no. 8: 805.
https://doi.org/10.3390/jpm14080805
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.