Pilot Study of Personalized Transcranial Magnetic Stimulation with Spectral Electroencephalogram Analyses for Assessing and Treating Persons with Autism
Abstract
:1. Introduction
2. Methods
2.1. Subjects
2.2. PrTMS Regimen
2.3. Data Analysis
3. Results
3.1. ASC Psychometric Tests
3.2. Spectral EEG
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Standard rTMS | Personalized rTMS |
---|---|---|
EEG | None | Every 5–7 treatments |
Spectral EEG analysis | None | Every 5–7 treatments |
Cortical region treated | DLPFC | Multiple locations |
Stimulation frequency | 10 Hz | Personalized, 3–5 diff freqs/patient |
Stimulation level (% motor threshold) | 120% | Reduced intensity/dynamic/custom |
Trains/session | 30 | Dynamic/custom |
Train length | 6 s | Dynamic/custom |
Interval length | 54 s | Dynamic/custom |
All | Before PrTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
---|---|---|---|---|
Total subjects | 53 | 53 | 43 | 43 |
Average score | 97 | 75 | 96 | 73 |
Number of males | 40 | 40 | 33 | 33 |
Number of females | 13 | 13 | 10 | 10 |
Age range | 1–34 | 1–34 | 1–34 | 1–34 |
Average age | 16 | 16 | 16 | 16 |
Median age | 17 | 17 | 18 | 18 |
Responders only | Before PrTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
Total subjects | 17 | 17 | 17 | 17 |
Average score | 90 | 43 | 90 | 43 |
Number of males | 14 | 14 | 14 | 14 |
Number of females | 3 | 3 | 3 | 3 |
Average range | 1–30 | 1–30 | 1–30 | 1–30 |
Average age | 18 | 18 | 18 | 18 |
Median age | 19 | 19 | 19 | 19 |
Nonresponders only | Before PrTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
Total subjects | 22 | 22 | 21 | 21 |
Average score | 103 | 98 | 105 | 100 |
Number of males | 16 | 16 | 15 | 15 |
Number of females | 6 | 6 | 6 | 6 |
Average range | 4–34 | 4–34 | 4–34 | 4–34 |
Average age | 14 | 14 | 14 | 14 |
Median age | 13 | 13 | 10 | 10 |
All | Before PRTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
---|---|---|---|---|
Total subjects | 70 | 70 | 70 | 70 |
Average score | 36 | 33 | 36 | 33 |
Number of males | 55 | 55 | 55 | 55 |
Number of females | 15 | 15 | 15 | 15 |
Age range | 0–61 | 0–61 | 0–61 | 0–61 |
Average age | 13 | 13 | 13 | 13 |
Median age | 11 | 11 | 11 | 11 |
Responders only | Before PrTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
Total subjects | 26 | 26 | 26 | 26 |
Average score | 35 | 29 | 35 | 29 |
Number of males | 16 | 16 | 16 | 16 |
Number of females | 10 | 10 | 10 | 10 |
Average range | 4–44 | 4–44 | 4–44 | 4–44 |
Average age | 12 | 12 | 12 | 12 |
Median age | 11 | 11 | 11 | 11 |
Nonresponders only | Before PrTMS | Treatment Week 4 | Before PrTMS | Treatment Week 6 |
Total subjects | 38 | 38 | 38 | 38 |
Average score | 37 | 36 | 37 | 36 |
Number of males | 33 | 33 | 33 | 33 |
Number of females | 5 | 5 | 5 | 5 |
Average range | 0–61 | 0–61 | 0–61 | 0–61 |
Average age | 13 | 13 | 13 | 13 |
Median age | 12 | 12 | 12 | 12 |
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Makale, M.T.; Nybo, C.; Blum, K.; Dennen, C.A.; Elman, I.; Murphy, K.T. Pilot Study of Personalized Transcranial Magnetic Stimulation with Spectral Electroencephalogram Analyses for Assessing and Treating Persons with Autism. J. Pers. Med. 2024, 14, 857. https://doi.org/10.3390/jpm14080857
Makale MT, Nybo C, Blum K, Dennen CA, Elman I, Murphy KT. Pilot Study of Personalized Transcranial Magnetic Stimulation with Spectral Electroencephalogram Analyses for Assessing and Treating Persons with Autism. Journal of Personalized Medicine. 2024; 14(8):857. https://doi.org/10.3390/jpm14080857
Chicago/Turabian StyleMakale, Milan T., Chad Nybo, Kenneth Blum, Catherine A. Dennen, Igor Elman, and Kevin T. Murphy. 2024. "Pilot Study of Personalized Transcranial Magnetic Stimulation with Spectral Electroencephalogram Analyses for Assessing and Treating Persons with Autism" Journal of Personalized Medicine 14, no. 8: 857. https://doi.org/10.3390/jpm14080857