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Epigenomes, Volume 3, Issue 4

2019 December - 1 articles

Cover Story: A pair of monozygotic twin artificial insemination (AI) Holstein bulls in China shared identical genetics and very similar appearances, but with discordant (Bull1 performed better than Bull2) sperm qualities and daughters’ fertility performance (~6000 daughters per bull). We wondered whether epigenetic modifications in their sperm cells contributed to the differences. By investigating the DNA methylomes and transcriptomes of the sperm cells, we observed higher global sperm methylation levels in Bull1 than in Bull2 and highlighted several fertility-related genes that were potentially epigenetically regulated. The results provided new insights into the influences of AI bull sperm methylomes on offspring fertility. View this paper.
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Articles (1)

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  • Open Access
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Divergence Analyses of Sperm DNA Methylomes between Monozygotic Twin AI Bulls

  • Shuli Liu,
  • Siqian Chen,
  • Wentao Cai,
  • Hongwei Yin,
  • Aoxing Liu,
  • Yanhua Li,
  • George E. Liu,
  • Yachun Wang,
  • Ying Yu and
  • Shengli Zhang
Epigenomes2019, 3(4), 21;https://doi.org/10.3390/epigenomes3040021

26 September 2019

Semen quality is critical for fertility. However, it is easily influenced by environmental factors and can induce subfertility in the next generations. Here, we aimed to assess the impacts of differentially methylated regions and genes on semen quali...

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Epigenomes - ISSN 2075-4655
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