Next Article in Journal
SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
Next Article in Special Issue
Environmental Epigenomes
Previous Article in Journal
Acknowledgment to the Reviewers of Epigenomes in 2022
Previous Article in Special Issue
Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms—An Insightful Perspective on Ecoepigenetics
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Epigenomes
Volume 7
Issue 1
10.3390/epigenomes7010004
epigenomes-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents

by
Abeer A. Aljahdali
1,2,
Jaclyn M. Goodrich
3,*,
Dana C. Dolinoy
2,3,
Hyungjin M. Kim
4,
Edward A. Ruiz-Narváez
2,
Ana Baylin
2,5,
Alejandra Cantoral
6,
Libni A. Torres-Olascoaga
7,
Martha M. Téllez-Rojo
7 and
Karen E. Peterson
2,3
1
Department of Clinical Nutrition, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2
Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA
3
Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA
4
Center for Computing, Analytics and Research, University of Michigan, Ann Arbor, MI 48109, USA
5
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
6
Department of Health, Iberoamericana University, Mexico City 01219, Mexico
7
Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca 62100, Mexico
*
Author to whom correspondence should be addressed.
Epigenomes 2023, 7(1), 4; https://doi.org/10.3390/epigenomes7010004
Submission received: 13 January 2023 / Revised: 28 January 2023 / Accepted: 29 January 2023 / Published: 3 February 2023
(This article belongs to the Special Issue Environmental Epigenomes)
Browse Figure
Review Reports Versions Notes

Abstract

DNA methylation (DNAm) is a plausible mechanism underlying cardiometabolic abnormalities, but evidence is limited among youth. This analysis included 410 offspring of the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort followed up to two time points in late childhood/adolescence. At Time 1, DNAm was quantified in blood leukocytes at long interspersed nuclear elements (LINE-1), H19, and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD-2), and at Time 2 in peroxisome proliferator-activated receptor alpha (PPAR-α). At each time point, cardiometabolic risk factors were assessed including lipid profiles, glucose, blood pressure, and anthropometry. Linear mixed effects models were used for LINE-1, H19, and 11β-HSD-2 to account for the repeated-measure outcomes. Linear regression models were conducted for the cross-sectional association between PPAR-α with the outcomes. DNAm at LINE-1 was associated with log glucose at site 1 [β = −0.029, p = 0.0006] and with log high-density lipoprotein cholesterol at site 3 [β = 0.063, p = 0.0072]. 11β-HSD-2 DNAm at site 4 was associated with log glucose (β = −0.018, p = 0.0018). DNAm at LINE-1 and 11β-HSD-2 was associated with few cardiometabolic risk factors among youth in a locus-specific manner. These findings underscore the potential for epigenetic biomarkers to increase our understanding of cardiometabolic risk earlier in life.
Keywords: cardiometabolic risk factors; population-based study; children and adolescents; Mexicans; biomarkers; epigenetics; DNA methylation cardiometabolic risk factors; population-based study; children and adolescents; Mexicans; biomarkers; epigenetics; DNA methylation

Share and Cite

MDPI and ACS Style

Aljahdali, A.A.; Goodrich, J.M.; Dolinoy, D.C.; Kim, H.M.; Ruiz-Narváez, E.A.; Baylin, A.; Cantoral, A.; Torres-Olascoaga, L.A.; Téllez-Rojo, M.M.; Peterson, K.E. DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents. Epigenomes 2023, 7, 4. https://doi.org/10.3390/epigenomes7010004

AMA Style

Aljahdali AA, Goodrich JM, Dolinoy DC, Kim HM, Ruiz-Narváez EA, Baylin A, Cantoral A, Torres-Olascoaga LA, Téllez-Rojo MM, Peterson KE. DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents. Epigenomes. 2023; 7(1):4. https://doi.org/10.3390/epigenomes7010004

Chicago/Turabian Style

Aljahdali, Abeer A., Jaclyn M. Goodrich, Dana C. Dolinoy, Hyungjin M. Kim, Edward A. Ruiz-Narváez, Ana Baylin, Alejandra Cantoral, Libni A. Torres-Olascoaga, Martha M. Téllez-Rojo, and Karen E. Peterson. 2023. "DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents" Epigenomes 7, no. 1: 4. https://doi.org/10.3390/epigenomes7010004

APA Style

Aljahdali, A. A., Goodrich, J. M., Dolinoy, D. C., Kim, H. M., Ruiz-Narváez, E. A., Baylin, A., Cantoral, A., Torres-Olascoaga, L. A., Téllez-Rojo, M. M., & Peterson, K. E. (2023). DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents. Epigenomes, 7(1), 4. https://doi.org/10.3390/epigenomes7010004

Article Metrics

Back to TopTop