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Antioxidants
Volume 10
Issue 2
10.3390/antiox10020252
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Article

Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes

by
Sakan Warinhomhoun
1,
Chawanphat Muangnoi
2,3,
Visarut Buranasudja
4,
Wanwimon Mekboonsonglarp
5,
Pornchai Rojsitthisak
3,6,
Kittisak Likhitwitayawuid
1 and
Boonchoo Sritularak
1,3,*
1
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
2
Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand
3
Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
4
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
5
Scientific and Technological Research Equipment Centre, Chulalongkorn University, Bangkok 10330, Thailand
6
Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(2), 252; https://doi.org/10.3390/antiox10020252
Submission received: 11 January 2021 / Revised: 28 January 2021 / Accepted: 3 February 2021 / Published: 6 February 2021
(This article belongs to the Special Issue Oxidative Stress and Skin Disease: Genetics, Etiopathogenesis, Possible Therapeutic Approaches of Antioxidant Therapies)
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Abstract

Five compounds including a new bisbibenzyl named dendropachol (1) and four known compounds (2–5) comprising 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2), gigantol (3), moscatilin (4) and 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (5) were isolated from a methanolic extract of Dendrobium pachyglossum (Orchidaceae). The chemical structures of the isolated compounds were characterized by spectroscopic methods. Dendropachol (1) was investigated for its protective effects on hydrogen peroxide (H2O2)-induced oxidative stress in HaCaT keratinocytes. Compound 1 showed strong free radical scavenging compared to the positive control. For the cytoprotective effect, compound 1 increased the activities of GPx and CAT and the level of GSH but reduced intracellular reactive oxygen species (ROS) generation and accumulation. In addition, compound 1 significantly diminished the expression of p53, Bax, and cytochrome C proteins, decreased the activities of caspase-3 and caspase-9, and increased Bcl-2 protein. The results suggested that compound 1 exhibited antioxidant activities and protective effects in keratinocytes against oxidative stress induced by H2O2.
Keywords: Dendrobium pachyglossum; Orchidaceae; dendropachol; bisbibenzyl; antioxidant Dendrobium pachyglossum; Orchidaceae; dendropachol; bisbibenzyl; antioxidant
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MDPI and ACS Style

Warinhomhoun, S.; Muangnoi, C.; Buranasudja, V.; Mekboonsonglarp, W.; Rojsitthisak, P.; Likhitwitayawuid, K.; Sritularak, B. Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes. Antioxidants 2021, 10, 252. https://doi.org/10.3390/antiox10020252

AMA Style

Warinhomhoun S, Muangnoi C, Buranasudja V, Mekboonsonglarp W, Rojsitthisak P, Likhitwitayawuid K, Sritularak B. Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes. Antioxidants. 2021; 10(2):252. https://doi.org/10.3390/antiox10020252

Chicago/Turabian Style

Warinhomhoun, Sakan, Chawanphat Muangnoi, Visarut Buranasudja, Wanwimon Mekboonsonglarp, Pornchai Rojsitthisak, Kittisak Likhitwitayawuid, and Boonchoo Sritularak. 2021. "Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes" Antioxidants 10, no. 2: 252. https://doi.org/10.3390/antiox10020252

APA Style

Warinhomhoun, S., Muangnoi, C., Buranasudja, V., Mekboonsonglarp, W., Rojsitthisak, P., Likhitwitayawuid, K., & Sritularak, B. (2021). Antioxidant Activities and Protective Effects of Dendropachol, a New Bisbibenzyl Compound from Dendrobium pachyglossum, on Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Keratinocytes. Antioxidants, 10(2), 252. https://doi.org/10.3390/antiox10020252

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